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Simply Progesterone 1.08 oz

(93 reviews) Write a Review
  • Simply Progesterone - Molecular Serum
  • Simply Progesterone - Product label


Simply Progesterone is a molecular progesterone serum that is so effective and refined that our competitors have not duplicated it since 2010.

USP Progesterone, Vitamin E & MCT Oil in Perfect Balance.

Known Customs Restrictions: Canada, Germany *
Due to the nature of this product, some countries may consider it regulated or prohibited from importation. Please see our policies. * This is not a comprehensive list; we will post updates as we become aware of them.

It's the most effective non-prescription progesterone on the market today.

  • Silky smooth texture.
  • The balanced formula penetrates deep into the skin delivering progesterone where it counts. *
  • Nourishing formula feeds the skin & body. *
  • Promotes circulation to enhance progesterone delivery. *
  • Gentle & balancing hormone therapy. *
  • Helps replicate the body's steady production of progesterone when used as directed. *
  • Vegan. *

Three Simple Ingredients.

We believe if it touches your skin, it should be the good for the whole body.

  1. Bio-identical Progesterone - Naturally derived, USP, Pharmaceutical grade, and chemical free.
  2. Vitamin E - Naturally derived, low temperature, molecularly distilled mixed tocopherols. **
  3. MCT oil - Ultra purified and ethically sourced.

Get What You Pay For - We Don't Cut Corners with Cheap, Unsafe Ingredients.

All of our ingredients come from the top global producers for their specialty. Most companies buy from the lowest bidder, not us. We've never compromised quality to reduce prices. Because we refuse to compromise, our price fluctuates up and down based on our cost.

Why topical Molecular Progesterone is better than oral progesterone.

Progesterone taken by mouth, either as pills or liquid, can cause the following problems:

  • It can worsen the symptoms you want to address.
  • Produces acute spikes and dips in progesterone levels that are unnatural.
  • Stresses the body.
  • Increases estrogen levels as the body tries to detox excess progesterone.
  • Triggers imbalances between progesterone, estrogen, and testosterone.

Simply put, Simply Progesterone delivers the steady hormone levels that your body expects and needs for you to feel your best. When applied to the skin as directed, Simply Progesterone delivers progesterone slowly through the skin, duplicating the body's natural rate of gentle progesterone production.


3 mg per drop.
100 mg per ml.

Suggested Use:

2-3 drops applied to the skin twice daily. Read the blog post below for detailed instructions.

How to use Simply Progesterone - Dr. Kassner's detailed protocol on using molecular progesterone serum to optimize your health.


Volume: ~32 ml (1.08 ounces). Total progesterone per bottle: ~2,700 mg.
Drops per bottle: Approximately 900.

How long will a bottle last? To calculate how many days a bottle will last, Divide 900 by the number of drops you expect to use daily.

@ 6 drops/day = ~150 day supply.
@ 10 drops/day = ~90 day supply.
@ 15 drops/day = ~60 day supply.
@ 20 drops/day = ~45 day supply.
Use within one year of opening.

 Learn why progesterone creams don't work.

** Mixed tocopherols are derived from non-GMO soy. This type of vitamin E is refined with a method that renders it FDA certified as "Soy Allergen Free."

International Notice: The following countries reject this product regularly. *
- Canada - 4/01/24 - About 60% of Progesterone are being blocked by Canadian customs. 
Our Guaranteed Delivery Policy no longer covers this product to the listed destinations above. If any destination above refuses your package, we will not refund shipping or any products not returned to us.

Note: This is our list of problem destinations and does not constitute legal advice. You are responsible for knowing if a product is allowed for import.

NOTE: This product has a distinct aroma that is the result of our low temperature process.

Processing progesterone with raw, mixed tocopherols creates a distinct odor. Some people may find that it smells rancid to slightly fishy, it is not rancid. We do not add additional ingredients or high heat to deodorize our formula.

The odor of this product can vary from batch to batch, this is due to normal variations in the raw tocopherols we use. We have chosen not to mask this natural variation with additional ingredients, or high heat processing.

Care and Storage:

Use within 1 year of opening.
After opening, keep tightly sealed and store at room temperature in a dry location away from light.
Do not refrigerate after opening; doing so will increase the uptake of moisture and spoil this product. This product may be refrigerated if the original manufacturer's seal has not been broken.

Warning: This product contains a chemical [Progesterone] known to the State of California's Prop. 65 to cause cancer. 



Q: Is Simply Progesterone safe to take internally?

A: We can't tell you that without violating Federal Law. What we can tell you is that the vitamin E and MCT oil we use in Simply Progesterone is the same as we use for other products in our line like Whole E

Q: Why does Simply Progesterone now have a cancer warning on the label?

A: We are updating the legal compliance of our labels. The State of California's Proposition 65 has a list of products that must have this warning on the label to be allowed for sale within its borders. Progesterone is on that list. 

Q: Where should I apply this product?

A: Simply Progesterone is best applied to soft inner skin like the abdomen, or the insides of the arms and thighs. Use a different location each day.

Q: Can I rub Simply Progesterone into the gums of my mouth?

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I consume Simply Progesterone orally or by mouth?

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I apply Simply Progesterone inside my vagina? 

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I apply Simply Progesterone to my labia? 

A: Yes, the topical application of OTC progesterone is allowed by the FDA. Simply Progesterone contains non-irritating ingredients and is gentle on sensitive skin. 



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93 Reviews

  • 5

    Simply Progesterone

    Posted by Gail on Jul 15th 2024

    My body loves it!! Thank you so very much. It is a game changer for me.

  • 5

    Simply Progesterone

    Posted by Unknown on Jul 3rd 2024

    I was afraid it would taste rancid from the oi, but there is almost no taste. The best part is I'm calmer now and I've been sleeping better than I have in the last 25 years. Wish I had this a long time ago.

  • 5

    Simply Progesterone

    Posted by Blondie137 on Jun 30th 2024

    This product works great for me. I get pain from endometriosis frequently, and taking this regularly helps with the pain.

  • 5


    Posted by Sue on Jun 30th 2024

    Since taking this for a few weeks now, I have been sleeping a bit better and less anxious … as I have in the past when on natural progesterone from a compounding pharmacy in my country. After a break of a couple of years I wanted to take progesterone again for its calming and sleeping helping effects and am very satisfied with this product. Note that needs to be taken with the dropper not to deliver too much. 10 drops is about 30mg, and care needs to be taken when returning the dropper to the bottle or you end up with some dribbling down the side. There are many benefits to bioidentical progesterone, even for post menopausal women and I recommend highly.

  • 5

    Simply Progesterone

    Posted by Ellen on May 20th 2024

    Works Well! I am pleased with the Simply Progesterone.

  • 5

    Simply Progesterone

    Posted by Florence Arquitt on Apr 17th 2024

    This product has changed my life. Even though I was not having menopause symptoms, I knew my hormones were off. I am sleeping better and calmer. I also bought this product for my daughter that had painful menstrual cycles and migraines, after the first month of being on the product, NO MORE painful menstrual cycles and NO MORE migraines. This product has been life changing for us both. Thank you for offering a quality product!

  • 4

    Simply Progesterone

    Posted by Debbie Thompson on Apr 15th 2024

    No more hot flashes!!

  • 5

    Best progesterone

    Posted by Melody on Mar 6th 2024

    I would say this is the best progesterone I’ve ever used. It’s easier to rub in because of the small drops of oil vs cream. It seems to work more effectively at stopping the spotting I was having in between cycles. I won’t use anything else going forward.

  • 1

    Did nothing for me

    Posted by Vicki Streit on Mar 5th 2024

    I purchased this hoping it would allow me to stop taking the bioidentical HRT troche I've been on since 2008 following a total hysterectomy. My hot flashes and night sweats have returned with a vengeance and I am miserable! So, I have resumed taking the troche and am now left with two partial bottles of unusable progesterone. In addition to this not helping my menopausal symptoms, I have developed an odd body odor that I've never had before. I don't know if this is related to the progesterone, but it's the only thing I've done differently recently. I had really high hopes for this product since it was recommended by Dr. Joseph Mercola, but it was a huge fail for me. Health Natura: I'm sorry to hear that you didn't have a good experience with Simply Progesterone. It doesn't work for everyone. We're happy to arrange a return and refund if you have any unopened products.

  • 5

    Amazing product

    Posted by Jenefer Hollins on Feb 22nd 2024

    I sure gladly to have this product which help me operate to my health stick to my immune system boosting my wellness.

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