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Simply Progesterone Oil 1oz

(133 reviews) Write a Review
  • Simply Progesterone 1.08 oz serum bottle with dropper in a balanced, natural formula, 'progesterone'.
  • Simply Progesterone 1.08 oz molecular serum dropper bottle with silky smooth texture.
  • Simply Progesterone 1.08 oz serum bottle label with USP Progesterone and green accents.
$59.99
Frequently bought together:

Description

Simply Progesterone is a molecular progesterone serum that is so effective and refined that our competitors have not duplicated it since 2010.

USP Progesterone, Vitamin E & MCT Oil in Perfect Balance.

Known Customs Restrictions: Canada, Germany, Netherlands, Poland, Spain *
Due to the nature of this product, some countries may consider it regulated or prohibited from importation. Please see our policies. * This is not a comprehensive list; we will post updates as we become aware of them.

“Why does nothing seem to work anymore?”

You try to sleep… and your mind won’t shut off.
You feel off… not like yourself… and you can’t explain it.
Your body used to feel steady… now it feels unpredictable.

And every product you try says the same thing:

“Supports hormone balance.”

So you try it…
Wait…
Hope…

And nothing really changes.


Here’s what most people never get told:

It’s not that your body is hard to help.

And it’s not that you haven’t tried enough.

It’s what’s inside the products you’ve been using.

Fillers.
Preservatives.
Weak formulas.

Things that look fine on a label…
And quietly get in the way once they’re in your body.


And that matters more than people think.

Because progesterone isn’t just something you “take.”

It’s something your body has to recognize
absorb
and actually use.

And when that process is disrupted…
You feel it.


What makes this different

Simply Progesterone Oil is built around one idea:

Remove what doesn’t belong.

No fillers
No preservatives
No unnecessary additives

Just clean progesterone in a simple oil base your body can work with.


What women often notice over time*

✔ A calmer, more settled feeling
✔ Easier nights and more consistent sleep
✔ Feeling more like themselves again
✔ Less of that “up and down” feeling throughout the day

(*Results vary. This is not medical advice.)

Simply Progesterone is a premium, bioidentical progesterone serum designed to support natural hormonal balance in a simple, effective way. Formulated for transdermal use, this lightweight oil absorbs easily through the skin, delivering progesterone directly into the bloodstream for consistent and efficient support.

As progesterone levels naturally fluctuate due to stress, age, or lifestyle factors, maintaining balance with estrogen becomes increasingly important. Simply Progesterone helps restore this balance, supporting overall endocrine health and promoting a more stable internal environment.

Beyond hormone support, progesterone is widely known for its calming influence on the body. Many users turn to Simply Progesterone to help promote a sense of relaxation, emotional stability, and resilience to everyday stress.

Crafted with clean, high-quality ingredients—including absorption-enhancing oils and antioxidants—Simply Progesterone offers a convenient, non-invasive way to support your body’s natural rhythms and well-being.

It's the most effective non-prescription progesterone on the market today.

  • Silky smooth texture.
  • The balanced formula penetrates deep into the skin, delivering progesterone where it counts. *
  • Nourishing formula feeds the skin & body. *
  • Promotes circulation to enhance progesterone delivery. *
  • Gentle & balancing. *
  • Helps replicate the body's steady production of progesterone when used as directed. *
  • Vegan. *

Three Simple Ingredients.

We believe if it touches your skin, it should be good for the whole body.

  1. Molecular Bio-identical Progesterone - Naturally derived, USP, Pharmaceutical grade, and chemical-free.
  2. Vitamin E - Naturally derived, low temperature, molecularly distilled mixed tocopherols. **
  3. MCT oil - Ultra-purified and ethically sourced from coconut & palm.

Allergens: Contains Coconut and Palm oils.

Get What You Pay For - We Don't Cut Corners with Cheap, Unsafe Ingredients.

All of our ingredients come from the top global producers for their specialty. Most companies buy from the lowest bidder, not us. We've never compromised quality to reduce prices. Because we refuse to compromise, our price fluctuates with our costs.

Why topical Molecular Progesterone is better than oral progesterone.

Progesterone taken by mouth, either as pills or liquid, can cause the following problems:

  • It can worsen the symptoms you want to address.
  • Causes side effects such as excessive fatigue by converting the highest percentage of the dose into allopregnenolone.
  • Produces acute spikes and dips in progesterone levels that are unnatural.
  • Stresses the body.
  • Triggers imbalances between progesterone, estrogen, and testosterone.

Simply put, Simply Progesterone delivers the steady hormone levels that your body expects and needs for you to feel your best. When applied to the skin as directed, Simply Progesterone delivers progesterone slowly through the skin, matching the body's natural, gentle progesterone production rate.

Concentration:

3 mg per drop.
100 mg per ml.

Suggested Use:

Start with 1-6 drops applied to the skin twice daily, and increase every 6 weeks as needed until you achieve symptom relief. Read the blog post How to use Simply Progesterone for detailed instructions.

Dosage note: If you are perimenopausal, you will need higher doses than if you are menopausal or postmenopausal. 

Progesterone Dosage Guide Based On Life Stage:

  1. Perimenopausal (Regular Cycle): up to 200 mg per day. (If menstruating regularly, cycle the progesterone by using it for 12 to 14 days during your cycle's second half, typically days 14 through 28. If your cycle has become irregular, follow the guidelines in section 2.) Note: Dosage requirements can fluctuate during this early phase of menopause. If you are feeling overly sedated, reduce the dose. If your symptoms reappear, increase the dose. If you feel overly sedated but still have symptoms, consider combined therapy with Simply Estriol or Simply Bi-Est.
  2. Perimenopause (Irregular Cycle): up to 150 mg per day. Gradually adjust the dose down from perimenopausal levels to the minimum needed to keep symptoms in remission. As your cycle changes, so do your hormonal requirements. No more cycling is required. (Once menstruation becomes irregular, progesterone requirements change. Switch from cyclical use as outlined in section 1 and start with continuous use.)
  3. Menopause (Cycle Has Stopped): up to 100 mg daily. Use continuously, no need to cycle. Gradually adjust the dose down to the minimum needed to maintain symptom remission.
  4. Post Menopause (10 since last cycle): up to 100 mg daily. Use continuously, no need to cycle. Gradually adjust the dose down to the minimum needed to maintain symptom remission.

Progesterone Application Locations

Apply to soft inner skin and rotate application locations to minimize tissue saturation. All of our products are for topical use only.

Best locations for systemic absorption: Progesterone can be applied to the face, inner arms, upper chest, inner thighs, and lower abdomen. Avoid direct application to the breast to prevent progesterone buildup in breast tissue.

Best location for uterine protection: The best application location that focuses progesterone concentration in uterine tissue is the genitalia: vulva, inner & outer labia. This zone preferentially absorbs hormones and does not need to be rotated, unlike the other skin types listed above.

  • Mouth/Gum and Oral use is not advised as these routes promote the highest conversion of progesterone to allopregnenolone and produce the most side effects. OTC hormones are legal for topical and cosmetic use only.
  • Transdermal application yields the highest and most steady blood levels of active progesterone.

Note: Start low and gradually increase to avoid experiencing unwanted side effects. Many people find that they feel optimized on doses lower than those listed above. Only 20% of women do well on a progesterone-only therapy, 80% need to add Simply Estriol or Simply Bi-Est (estriol/estradiol combo) to achieve optimal results.

How to use Simply Progesterone - Dr. Kassner's detailed protocol on using molecular progesterone serum to optimize your health.

Specifications:

Volume: ~32 ml (1.08 ounces). Total progesterone per bottle: ~2,700 mg.
Drops per bottle: Approximately 900.

How long will a bottle last? To calculate how many days a bottle will last, Divide 900 by the number of drops you expect to use daily.

@ 6 drops/day = ~150 day supply.
@ 10 drops/day = ~90 day supply.
@ 15 drops/day = ~60 day supply.
@ 20 drops/day = ~45 day supply.
@ 1 dropper full (100 mg)/day = ~30 day supply.

Use within one year of opening.

** Mixed tocopherols are derived from non-GMO soy. This type of vitamin E is refined with a method that renders it FDA certified as "Soy Allergen Free."

International Notice: The following countries reject this product regularly. *
- Canada - 4/01/24 - About 60% of Progesterone are being blocked by Canadian customs. 
Our Guaranteed Delivery Policy no longer covers this product to the listed destinations above. If any destination above refuses your package, we will not refund shipping or any products not returned to us.

Note: This is our list of problem destinations and does not constitute legal advice. You are responsible for knowing if a product is allowed for import.

NOTE: This product has a distinct aroma that is the result of our low temperature process.

Processing progesterone with raw, mixed tocopherols creates a distinct odor. Some people may find that it smells rancid to slightly fishy, it is not rancid. We do not add additional ingredients or high heat to deodorize our formula.

The odor of this product can vary from batch to batch, this is due to normal variations in the raw tocopherols we use. We have chosen not to mask this natural variation with additional ingredients, or high heat processing.

Care and Storage:

THIS PRODUCT IS PRESERVATIVE FREE.
Use within 1 year of opening.
After opening, keep tightly sealed and store at room temperature in a dry location away from light.
Do not refrigerate after opening; doing so will increase the uptake of moisture and spoil this product. This product may be refrigerated if the original manufacturer's seal has not been broken.

Warning: This product contains a chemical [Progesterone] known to the State of California's Prop. 65 to cause cancer. 

FAQ:

Q: Is Simply Progesterone safe to take internally?

A: We can't tell you that without violating Federal Law. What we can tell you is that the vitamin E and MCT oil we use in Simply Progesterone is the same as we use for other products in our line like Whole E

Q: Why does Simply Progesterone now have a cancer warning on the label?

A: We are updating the legal compliance of our labels. The State of California's Proposition 65 has a list of products that must have this warning on the label to be allowed for sale within its borders. Progesterone is on that list. 

Q: Where should I apply this product?

A: Simply Progesterone is best applied to soft inner skin, like the abdomen, or the insides of the arms and thighs. Use a different location each day.

Q: Can I rub Simply Progesterone into the gums of my mouth?

A: No. The FDA requires all OTC, non-prescription progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I consume Simply Progesterone orally or by mouth?

A: The FDA requires all OTC, non-prescription progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I apply Simply Progesterone inside my vagina? 

A: Yes, the topical application of OTC progesterone is allowed by the FDA. Simply Progesterone contains non-irritating ingredients and is gentle on sensitive skin.

Q: Can I apply Simply Progesterone to my labia or vagina? 

A: Yes, the topical application of OTC progesterone is allowed by the FDA. Simply Progesterone contains non-irritating ingredients and is gentle on sensitive skin. 

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133 Reviews

  • 5

    Simply Progesterone

    Posted by Nancy on Mar 5th 2026

    Easy to use and I definitely sleep better. At 76 years old, I consistently score "Good" or "Excellent" with sleep tracking on my watch. According to stats, that is far above the "norm" for people my age. Thanks, Progesterone!!!

  • 5

    simply progesterone

    Posted by Louise on Mar 2nd 2026

    I use it about 1-2 times a week and seems to help me sleep deeply and gives me a sense of balance.

  • 5

    Progesterone

    Posted by Stacey on Jan 12th 2026

    Very high quality product that is easy to use and works. I sleep better and it helps balance my estrogen. I like all of their products. The specific written support has been a little vague because of the pressures from the FDA nowadays but I don't hold it against this company, it's like that everywhere.

  • 5

    Love it

    Posted by Mary Sabat on Nov 16th 2025

    I finally am able to get my progesterone levels up. I love this!

  • 5

    Progesterone

    Posted by Jody on Aug 20th 2025

    I’m very happy with the product. It has totally balanced out my hormones. I’m back to my happy and positive self. Thank you so much:)

  • 5

    Simply Progesterone

    Posted by Gregory on Aug 19th 2025

    3 or 4 drops before bed have improved my sleep immensely. Thank you!

  • 5

    Simply progesterone

    Posted by Nancy g on Jul 29th 2025

    Great product in glass bottle.

  • 5

    Progesterone Effectiveness

    Posted by Nancy on Jul 29th 2025

    I use Simply Progesterone nightly, allowing consistent deep sleep.

  • 5

    Simply Progesterone

    Posted by Janis on Jul 29th 2025

    This product is so easy to use and the results are amazing. I went from nightsweats and not sleeping for more than 2-3 hours, to sleeping for 6+ hours or more and no more nightsweats! The price is so reasonable for what you get in results.

  • 5

    Health Natural's progesterone is really working for me to regulate my hormonal system.

    Posted by Rubi D. on Jun 12th 2025

    I'm in menopause and I was having a really bad time until I found Health Natura products. I've been using them for over six months and the results have been phenomenal.

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