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Simply Progesterone 1.08 oz

(89 reviews) Write a Review


Simply Progesterone is a molecular progesterone serum that is so effective and refined that our competitors have not duplicated it since 2010.

USP Progesterone, Vitamin E & MCT Oil in Perfect Balance.

Known Customs Restrictions: Canada, Germany *
Due to the nature of this product, some countries may consider it regulated or prohibited from importation. Please see our policies. * This is not a comprehensive list; we will post updates as we become aware of them.

It's the most effective non-prescription progesterone on the market today.

  • Silky smooth texture.
  • The balanced formula penetrates deep into the skin delivering progesterone where it counts. *
  • Nourishing formula feeds the skin & body. *
  • Promotes circulation to enhance progesterone delivery. *
  • Gentle & balancing hormone therapy. *
  • Helps replicate the body's steady production of progesterone when used as directed. *
  • Vegan. *

Three Simple Ingredients.

We believe if it touches your skin, it should be the good for the whole body.

  1. Bio-identical Progesterone - Naturally derived, USP, Pharmaceutical grade, and chemical free.
  2. Vitamin E - Naturally derived, low temperature, molecularly distilled mixed tocopherols. **
  3. MCT oil - Ultra purified and ethically sourced.

Get What You Pay For - We Don't Cut Corners with Cheap, Unsafe Ingredients.

All of our ingredients come from the top global producers for their specialty. Most companies buy from the lowest bidder, not us. We've never compromised quality to reduce prices. Because we refuse to compromise, our price fluctuates up and down based on our cost.

Why topical Molecular Progesterone is better than oral progesterone.

Progesterone taken by mouth, either as pills or liquid, can cause the following problems:

  • It can worsen the symptoms you want to address.
  • Produces acute spikes and dips in progesterone levels that are unnatural.
  • Stresses the body.
  • Increases estrogen levels as the body tries to detox excess progesterone.
  • Triggers imbalances between progesterone, estrogen, and testosterone.

Simply put, Simply Progesterone delivers the steady hormone levels that your body expects and needs for you to feel your best. When applied to the skin as directed, Simply Progesterone delivers progesterone slowly through the skin, duplicating the body's natural rate of gentle progesterone production.


3 mg per drop.
100 mg per ml.

Suggested Use:

2-3 drops applied to the skin twice daily. Read the blog post below for detailed instructions.

How to use Simply Progesterone - Dr. Kassner's detailed protocol on using molecular progesterone serum to optimize your health.


Volume: ~32 ml (1.08 ounces). Total progesterone per bottle: ~2,700 mg.
Drops per bottle: Approximately 900.

How long will a bottle last? To calculate how many days a bottle will last, Divide 900 by the number of drops you expect to use daily.

@ 6 drops/day = ~150 day supply.
@ 10 drops/day = ~90 day supply.
@ 15 drops/day = ~60 day supply.
@ 20 drops/day = ~45 day supply.
Use within one year of opening.

 Learn why progesterone creams don't work.

** Mixed tocopherols are derived from non-GMO soy. This type of vitamin E is refined with a method that renders it FDA certified as "Soy Allergen Free."

International Notice: The following countries reject this product regularly. *
- Canada - 4/01/24 - About 60% of Progesterone are being blocked by Canadian customs. 
Our Guaranteed Delivery Policy no longer covers this product to the listed destinations above. If any destination above refuses your package, we will not refund shipping or any products not returned to us.

Note: This is our list of problem destinations and does not constitute legal advice. You are responsible for knowing if a product is allowed for import.

NOTE: This product has a distinct aroma that is the result of our low temperature process.

Processing progesterone with raw, mixed tocopherols creates a distinct odor. Some people may find that it smells rancid to slightly fishy, it is not rancid. We do not add additional ingredients or high heat to deodorize our formula.

The odor of this product can vary from batch to batch, this is due to normal variations in the raw tocopherols we use. We have chosen not to mask this natural variation with additional ingredients, or high heat processing.

Care and Storage:

Use within 1 year of opening.
After opening, keep tightly sealed and store at room temperature in a dry location away from light.
Do not refrigerate after opening; doing so will increase the uptake of moisture and spoil this product. This product may be refrigerated if the original manufacturer's seal has not been broken.

Warning: This product contains a chemical [Progesterone] known to the State of California's Prop. 65 to cause cancer. 



Q: Is Simply Progesterone safe to take internally?

A: We can't tell you that without violating Federal Law. What we can tell you is that the vitamin E and MCT oil we use in Simply Progesterone is the same as we use for other products in our line like Whole E

Q: Why does Simply Progesterone now have a cancer warning on the label?

A: We are updating the legal compliance of our labels. The State of California's Proposition 65 has a list of products that must have this warning on the label to be allowed for sale within its borders. Progesterone is on that list. 

Q: Where should I apply this product?

A: Simply Progesterone is best applied to soft inner skin like the abdomen, or the insides of the arms and thighs. Use a different location each day.

Q: Can I rub Simply Progesterone into the gums of my mouth?

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I consume Simply Progesterone orally or by mouth?

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I apply Simply Progesterone inside my vagina? 

A: The FDA requires all OTC; Non-prescription Progesterone to be labeled for topical & cosmetic use only. We cannot promote the internal use of Simply Progesterone. Doing so would prompt the FDA to reclassify Simply Progesterone as a drug, and we would be forced to stop selling it.

Q: Can I apply Simply Progesterone to my labia? 

A: Yes, the topical application of OTC progesterone is allowed by the FDA. Simply Progesterone contains non-irritating ingredients and is gentle on sensitive skin. 



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89 Reviews

  • 2

    Messy Dropper, Made with Soy

    Posted by LL on Feb 17th 2024

    This product is very expensive when you lose a third to a half with the messy dropper. It's a normal glass bottle and dropper, but the combo does not work with this thick product. The liquid oozes down the bottle and onto the counter again and again, no matter how careful I am! After I ordered, I realized this was made from estrogenic soy - yikes! I'm trying to lower estrogen, not raise it! As far as the description of being "silky smooth," it is smoother than a similar product made with vitamin E, but it is still sticky and not that easy to get absorbed. Really disappointed. Customer Service Reply: We're sorry to hear that you received a defective dropper. It should not leak like that. Please contact us and we will send you a replacement or give you a refund.

  • 5


    Posted by Pam on Jan 21st 2024

    I will have a blood test in months, but so far its a great product, easy to use and no side effects

  • 2

    Did not get good results

    Posted by Suzanne Hollandsworth on Jan 21st 2024

    This caused me brain fog. I used the recommended amount. Customer service response. Thank you for your feedback. We're sorry you had a negative experience with our Simply Progesterone. Products that contain hormones are not for everyone. Progesterone can be sedating for some people.

  • 4

    Oil Used

    Posted by D on Dec 6th 2023

    Was told the oil used was Vitamin E, but that is not the oil used in product received

  • 5

    Great product

    Posted by Paula on Oct 5th 2023

    This progesterone is very high quality. It really helps me relax and sleep well. Just a few drops twice a day works great for me. After researching many progesterone products I chose this one and so happy I did!

  • 5

    Simply Progesterone

    Posted by Karen on Sep 12th 2023

    I love that it only takes a few drops and easily rubs in.

  • 5

    Simply Progesterone

    Posted by Kim on Aug 2nd 2023

    Works wonderfully for me!

  • 5


    Posted by Kevin Hadsell on Nov 13th 2022

    I don't want to ramble, but I could go on and on, and I know how difficult it is to create a stellar product, and there is so much junk out there that gets great reviews, and no one questions that there are products out there worthy of a 5 star rating, and ones that are deserving of such praise. Words are so cheap when applied insincerely, or worse in ignorance, and not all ignorance is the same. There are many people who just don't know what a good product is in an ocean of garbage. This is the cream that rises to the top, and being in the health industry for many years, and witnessed cutting edge technology up close and personal, I don't think a compliment is unwarranted and therefore deserved. I do feel paying less for a cheaper version is truly flushing money down the drain, and I have done it myself. I am not of the opinion that paying more means more, and I have seen that side of the retail health market as well(usually pyramid schemes) Most of your work will go unnoticed and unappreciated, but there are a few of us that are taking note, and benefitting and then without coercion telling others where the treasure is.

  • 5

    Great product

    Posted by Ben on May 22nd 2022

    Recommended, will buy again

  • 5

    Simply Progesterone

    Posted by Nicole on Jun 19th 2021

    I have tried many different progesterone products and I think this is the best. Minimal ingredients, that are stable and do not require refrigeration, easy to use, glass bottle, and quick delivery make me love this product even more.

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