Experience steady, balanced hormonal therapy the way your body craves by replicating your body's natural pregnenolone production with topical pregnenolone oil.

When your body produces pregnenolone, it does so constantly and steadily over time, not in big doses a few times a day. Large doses of pregnenolone taken by mouth can be stressful on the body, producing the very symptoms you're trying to relieve! How? By creating unsteady hormone spikes and dips that your body may not appreciate. We now have the solution with our topical pregnenolone oil. Get 24 hours of sustained pregnenolone levels by applying this silky smooth transdermal pregnenolone oil to your skin twice daily. Get better results with lower doses.

USP Pregnenolone, Vitamin E & MCT Oil in Perfect Balance.

Known Customs Restrictions: Canada, Germany, Poland *

Due to the nature of this product, some countries may consider it regulated or prohibited from importation. Please see our policies. * This is not a comprehensive list; we will post updates as we become aware of them.

It's the most effective liquid pregnenolone on the market today.

• Silky smooth texture.
• The balanced formula penetrates deep into the skin, delivering pregnenolone where it counts. *
• Nourishing formula feeds the skin & body. *
• Promotes circulation to enhance pregnenolone delivery. *
• Gentle & balancing hormone therapy. *
• Replicates the body's steady production of pregnenolone when used as directed. *
• Vegan. *

Three Simple Ingredients.

If it touches your skin, it should be good for the whole body.

1. Bio-identical Pregnenolone - Naturally derived, USP, Pharmaceutical grade, and chemical free.
2. Vitamin E - Naturally derived, low temperature, molecularly distilled. **
3. MCT oil - Ultra purified and ethically sourced from coconut & palm.

Allergens: Contains Coconut and Palm oils.

Get What You Pay For - We Don't Cut Corners with Cheap, Unsafe Ingredients.

Concentration: One (1) drop = 4 mg.
Drops per bottle: Approximately 800.
Suggested Serving Size: 5-10 drops twice daily.
Five (5) drops = 20 mg.
Ten (10) drops = 40 mg.

Suggested Use

Gently massage the desired number of drops twice daily into the soft inner skin of the body. These thinner ventral regions of the skin include the insides of the arms, inner thighs, lower abdomen, upper chest, and around the belly button.
Shake well before use.
Safe for topical or oral use.

Articles:

Pregnenolone Explained: The Master Hormone You Need to Know About

Warning Signs of Low Pregnenolone for Women: What Your Body is Telling You

Why Choose Our Pregnenolone?

Not All Bioidentical Pregnenolone is Created Equal.

Naturally Processed - Industry Leading - Tested Quality Since 2000

We've been researching bioidentical pregnenolone for over 24 years. We know the dirty secrets and hidden gems of the pregnenolone industry inside and out. Who uses the latest science, is environmentally friendly, has high quality and standards, and WHO still uses toxic chemicals and polluting production methods. 

Cleaner than the best drinking water money can buy. 

Natural vs. Chemical Processing

Natural BioTransformation - Our pregnenolone supplier utilizes an environmentally friendly process called biotransformation. Biotransformation uses whole, non-GMO, wild yam tuber and transforms the active components directly into bio-identical pregnenolone. This cutting-edge pregnenolone biotechnology uses a series of special non-GMO micro-organisms to produce the world's cleanest pregnenolone leaving behind only compostable or recyclable waste. The finished pregnenolone is washed from the residual plant fiber using organic alcohol, dried, and ground into a micronized powder. The only remaining residue in the pregnenolone is a slight percentage of healthy waxy plant esters. Our purity ranges from 99.3 to 99.7 percent pure.

Chemical Processing - One 20-gram bottle of pregnenolone (derived from wild yam) produces over 230 pounds of unusable toxic waste from start to finish when made by chemical processing. 
Most companies still use chemical processing to produce pregnenolone, and there's nothing natural about the process. The starting material is a commercially cultivated hybrid of "wild yam." The first production step uses a series of acids, microwave radiation, and caustic soda to extract the compound diosgenin from the "wild yam." They then use a technique called Marker Degradation which uses a series of chemical treatments using acetic anhydride, chromic acid, acetic acid, and caustic soda to turn the diosgenin into pregnenolone. Multiple steps are then used to strip the pregnenolone of these dangerous chemicals before being crystalized and ground into a micronized powder. This basic process has many different versions, depending on the company, but it's essentially the same. 

Country of Origin: USA

Our Story

In late 2009, I visited our manufacturing partner in China. The owner's son was about my age (34 at the time) and had volunteered to conduct the tour of their plant. Eager to continue our visit, he insisted I join him for dinner at his favorite place. It had to have been the tiniest back-alley restaurant in Hong Kong! I would have been worried and hopelessly lost if we weren't friends. But it wasn't the excellent food that surprised me. It was a 2-page research paper he quietly slid my way under a glass of warm sake titled "Microbial Metabolism of Plant Sterols." After reading it, I shrugged my shoulders and started to hand it back to him. He immediately pushed it back and said, "Read... Again... Please." The second time through, it dawned on me. I was staring at the future of bioidentical pregnenolone and progesterone. My friend needed seed money to build a private lab to grow and test cultures. Simple. Right? Nope. What he did have was my seed money in less than 72 hours. We took possession and started distributing our first batch of biotransformed pregnenolone in 2019. Our confidentiality agreement allowed us to release this announcement as of August 1, 2023.

What is Pregnenolone Oil Used For?

Pregnenolone, the mother of all hormones, profoundly impacts your body as a precursor hormone that converts to other essential steroid hormones. As you age, pregnenolone levels naturally decline, making supplementation necessary. Produced in the adrenal glands above your kidneys, reduced function can lead to decreased hormone production. Pregnenolone oil effectively addresses several health concerns.

What is Pregnenolone Oil?

Pregnenolone Oil is a transdermal dietary supplement available over the counter—applied directly to the skin once daily. These oils are typically used in drop-dispensing bottles that deliver precise dosages, preventing overuse. Topical applications bypass the digestive system, entering the bloodstream directly. Your blood transports the hormone to receptors in organs and brain tissue.

Natural pregnenolone oil is derived from wild yams and synthesized to mimic your body's natural compound. Bioidentical pharmacies can create customized dosages for individual needs.

What is Pregnenolone Oil Used For?

Healthcare professionals recommend pregnenolone for numerous health concerns, from hormone balance to weight management. Below are the primary reasons for using pregnenolone oils.

Improves Cognitive Function

Brain health remains crucial throughout life. Pregnenolone benefits include fixing brain cell abnormalities that cause dementia, Alzheimer's Disease, brain fog, and memory issues. Pregnenolone oil effectively improves age-related cognitive conditions.

Lowers Inflammation.

Pregnenolone profoundly affects the immune system regulation of inflammation. This natural anti-inflammatory eases tight, inflamed skin at the source by dissolving proteins causing painful inflammation.

Tender red skin stems from conditions like eczema and psoriasis. These can flare up due to environmental factors or persist without a known cause. Inflamed skin creates discomfort and links to severe conditions like multiple sclerosis.

Provides PMS Support

Premenstrual syndrome affects most women during their reproductive years. For some, PMS brings severe inflammation (bloating), painful cramps, and tender breasts—plus moodiness, tiredness, and depression. Symptoms vary by woman and fluctuate monthly.

A transdermal pregnenolone oil provides an anti-inflammatory treatment for the nervous system, effectively reducing PMS symptoms.

Gives Hormonal Balance

Hormones are secret messengers circulating throughout your body. When imbalanced, painful symptoms emerge—from unexplained weight gain to severe mood swings.

Women typically experience hormonal concerns during menopause, when estrogen and progesterone levels drop severely. Men face imbalances connected to low testosterone or DHEA, causing low libido, depression, and weak muscles.

Strong evidence shows low hormone levels stem from low pregnenolone. Since pregnenolone is converted into other hormones, supplementation provides a natural balance of hormones.

Fights Depression

Depression is sustained sadness affecting mental health for days or weeks. For some, no direct cause or relief exists...

Pregnenolone supplementation addresses bipolar disorders and depression effectively. As a neurosteroid, pregnenolone benefits include improving brain pathways affecting thoughts and activity while treating abnormal brain cells impacting mental health.

Improves Sleep Quality

Sleep quality impacts every aspect of life—from work performance to relationships. Sleep deprivation occurs when stress overwhelms or pregnenolone levels drop.

Sleep follows circadian rhythms: light sleep transitions to deep sleep, then back to light rest. During light sleep, waking becomes more likely.

When this happens, falling asleep again proves difficult, reducing deep sleep time. Evidence shows pregnenolone promotes longer sleep cycles and prevents premature waking.

Promotes Weight Loss

Hormone levels directly affect weight management. Low hormones make weight loss harder or cause unexplained weight gain without lifestyle changes.

Pregnenolone boosts metabolism by stimulating natural hormone production through reduced cortisol. Cortisol—the stress hormone—helps you react to dangerous situations. But elevated cortisol creates chronic stress, significantly affecting weight and well-being.

Provides Immune System Support

A depleted immune system increases susceptibility to viruses and infections. Daily habits and genetics affect immune strength, but low pregnenolone weakens immunity.

Pregnenolone provides immune homeostasis—offering anti-inflammatory properties for body cells. This effect promotes immune function, reducing the frequency of illness and the time to recovery.

Pregnenolone oil lowers inflammation while boosting hormone levels naturally. The mother of all hormones provides essential protection...