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Methylene Blue 400mcg Ready to Use Solution 1oz

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  • Methylene Blue 400mcg per drop - Ready to Use Solution 1oz
  • Methylene Blue product label


Methylene Blue Tincture - 400 mcg per drop.

Made with care since 2012. Why Us? We've been a leading supplier long before the recent surge in popularity and fly by night brands all over the internet. 

Known Customs Restrictions *: Canada.
Due to the nature of this product, some countries may consider it regulated or prohibited from importation. Please see our policies. * This is not a comprehensive list; we will post updates as we become aware of them.

Product Specifications

Drops per bottle: 470.

Yield per drop: 400 mcg (micrograms) or 0.4 mg (milligrams)
Yield per 1 ml - 6.25 mg.

Solution Concentration: 0.63%

See bottom of page for formulary and molarity chart.

Purity Is Our Top Priority:

We spare no expense to ensure the absolute purest methylene blue on the market today. To detect any unexpected contaminants, we perform broad spectrum screening using FIRSA (far infrared spectrographic analysis), with qualitative and quantitative analysis before and after production. 
The finished product must meet the minimum requirements below before we will release it for sale. Contact us if you would like a copy of the most recent COA.


Acceptable Range (Results determined by high sensitivity FIRSA).


Limit in ppb (1)(2) Typical Result in ppb

Solvents other than organic alcohol.

 NSS (3)  2-5 
Pesticides & Herbicides  NSS  0-1 
Total Other Contaminants, fillers, plasticizers, etc.  NSS  0
Cadmium  5   0-1 
Lead  5   0-1 
Inorganic arsenic  15   0-2 
Inorganic mercury  30   0-1 
Iridium  100  0-10
Osmium  100  0
Palladium  100  0
Platinum  100  0-10
Rhodium  100  0
Ruthenium  100  0
Chromium  11000  10-30
Molybdenum  3000  0
Nickel  200  0-3
Vanadium  100  0
Copper  3000  0-12
Total metals excluding the above.  NSS 500-700
Microbiology  No Growth Pass

1. Limit based on USP/FDA specifications for oral drugs.
2. Parts Per Billion.
3. NSS (No Specified Standard).
4. Zero (0) is Below Level of Quantifiable Detection or ≤700 parts per trillion.


 How we got started with methylene blue

In 2011, our customers requested that I apply my distinctive collection of skills in naturopathy, TCM, chemistry, physics, and compounding to this frequently contaminated and biologically unique chemical. MethyleneBlu'  (formally Simply Methylene Blue) was born a year later and has grown in demand ever since. 

This ready to use solution is all you need to meet and exceed all of your research and laboratory needs. 

Simply Methylene Blue is made from the highest purity raw material on the market, analytical/chromatography standard. This level of purity is typically used to calibrate analytical equipment because it is highly refined and contaminant free. While this product exceeds all USP purity standards, it is not a nutritional supplement, and we cannot promote it for over-the-counter human consumption.

Ingredients: Methylene blue 400 mcg per drop, water, alcohol (from sugar cane).

Buyer's guide for methylene blue - Read time: 2-min.

What does Pharmaceutical Grade mean? 

First, the term "pharmaceutical grade" used outside the pharmaceutical industry is a ploy to make consumers think a product is better than others on the market or of the highest quality. If a product is not a pharmaceutical or is not a starting material for a drug, it is not pharmaceutical grade.

Anyone selling methylene blue that claims their product is "pharmaceutical grade" is misrepresenting their product. Which begs the question, what else are they hiding and misrepresenting?

MethyleneBlu' exceeds purity standards set by USP, meets cGMP manufacturing standards for sanitary and quality controls, and exceeds the purity standards required by the FDA for the production of pharmaceutical methylene blue. 

MethyleneBlu' is a highly pure methylene blue suitable for biomedical research, testing, equipment calibration, and other laboratory or research sensitive to contamination or other biologically incompatible ingredients. 

FDA Regulations That We Must Comply With.

There is a reason that we've been selling methylene blue longer than any other wellness company. We follow FDA Regulations. Asking us for any of the information in the list below is asking us to break the law and will cause the FDA to reclassify our product as a drug and force us to take it off the market.

  • Methylene Blue is not a nutritional supplement, and as the supplier, we are prohibited by the FDA from being an educational resource.
  • We cannot tell you how to use it in any way. 
  • We cannot promote its use in humans or animals, nor are we allowed to discuss its use on a practical or theoretical level.
  • We are prohibited from giving advice on human consumption of methylene blue, including dosage, consumption, application for any human condition, medical applications, its suitability for further compounding, or any other application.
  • MethyleneBlu' (Our Brand) is not a drug; it is not a pharmaceutical requiring a prescription. We do not advertise or promote it as a suitable replacement for any prescribed medication.
  • We cannot label or claim that this product is pharmaceutical grade because the FDA has only approved one source of prescription methylene blue to receive this designation. Making that claim would give the FDA reason to shut us down.


What else should I consider before purchasing methylene blue?

How long has the company has been making methylene blue? When it comes to methylene blue, experience is a big deal. A company could be in business for decades and only have a few weeks or months of experience with methylene blue. Sourcing pure methylene blue is not easy and has many complications unique to methylene blue.

Not all methylene blue is equal. The chemical everyone calls methylene blue is a wide range of products that vary in production quality, preparation, and composition. The real secret behind methylene blue and its use in biomedical research is it's a massive group of chemical preparations, all with different purities and intended applications. The biological implications of selecting the wrong material can significantly impact the results of your biomedical research. Because methylene blue is not approved for human consumption, there are no cGMP requirements, no sanitary or purity standards. 

We have been making ultra-pure, biomedical compatible methylene blue since 2012. We test every incoming batch of material with an infrared spectrograph to detect any foreign contaminants. We reject all batches that contain mercury or any other unexpected or unidentified spikes on the spectrographic results. After it passes this stage, we enter into our proprietary purification process to remove common contaminants such as arsenic, lead, copper, and zinc.

Is the company willing to publish or disclose a COA for their product? 

You can find the results of our typical COA above. Additionally, you may request a COA for any lot number for any batch we have produced since we started selling methylene blue.

If a company is not willing to offer this information freely, do not buy their product.

What does USP mean, and is it an important designation for methylene blue? 

USP is now considered a minimum quality standard in the industry. Additionally, USP is not a food-grade designation. The United States Pharmacopeia is a catalog of substances that are either drugs, are part of the drug production process, were once considered drugs, are considered food additives, or have been added to increase USP's income base. 

A USP certification only means that the substance has met USP's testing standards at least once in the last 12 months and has paid the USP organization their annual fee to use the USP designation. USP relies on companies to submit test results, does not require independent test results, and USP does not do any independent verification of the presented results.

What is Methylene Blue? 

Known as a heterocyclic aromatic chemical compound, with a chemical formula of C16H18ClN3S and a molar mass of 319.85 g/mol. It appears as a solid, odorless, dark green powder when held at room temperature. However, when mixed with water, the green powder dissolves and yields a characteristic blue solution that is extensively used in medicine and medical research.

Care and Storage:
Use within 1 year of opening.
After opening, keep tightly sealed and store at room temperature in a dry location away from light.
Do not refrigerate after opening; doing so will increase the potential for contamination and spoil this product. This product may be refrigerated if the original manufacturer's seal has not been broken.


Formulary & Conversions


Product Type: Solution
Active Ingredient CAS Number: 7220-79-3
Active Ingredient: Methylene Blue Trihydrate (Synonyms: C.I. Basic Blue 9 trihydrate)
Grade: USP *
Ingredients: Methylene Blue 400mcg per drop, water, alcohol.
Appearance: Iridescent blue-black liquid
Storage: Room temperature, away from light.
Chemical Formula: C16 H18 ClN3 S*3H2O
Solid Molecular Weight: 373.9 g/mol


Solution Concentration & Conversions:
Micrograms per drop: 400
Concentration: 0.63%
Grams per Milliliter: 0.0063
Milligrams per Milliliter: 6.3
Micrograms per Milliliter: 6,300
Molarity: 0.01684942
Millimolars: 16.84942
Micromollars: 16,849.42

* USP is not a universal designation for food grade or pharmaceutical grade. Many non-food substances are certified by USP.



Known Customs Restrictions Exist For This Product. We caution you against shipping this product to Canada.
Countries outside the US may consider this product a regulated substance and may reject or destroy it on arrival. Please see our policies on rejected international shipments for additional details.

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Additional Information

For Methylene Blue
Q: How much MB can I take?:
A: Because MB is not a nutritional supplement, we are prohibited from advising on the human applications of MB.
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18 Reviews

  • 5

    Methylene blue 400mcg

    Posted by Karen on Apr 28th 2024

    This is great for anti aging,it's also anti microbial,it works on the cells within the mitochondria functioning to repair damaged cells, plus helps with oxidated stress -It does much more, I use one little drop per ten lbs of body weight.,which I add into my daily electrolytes . It helps with mood swings, and increased energy along with red light therapy.

  • 5

    Methylene blue

    Posted by John Abenante on Jan 25th 2024

    Methylene blue is absolutely the best for energy and huge benefits for long term results. I highly recommend this product to reduce the mid day crash.

  • 5

    Methylene Blue

    Posted by Ray on Dec 27th 2023

    This is the first time I’ve taken MN. I love this product! When I was nearing the end of the bottle, which lasted almost 2 months for me, I bought 4 more. I’m grateful to Healthnatura for making this MB What

  • 5


    Posted by AZHealthNut on Nov 20th 2022

    Powerful--using topically before red light treatments. Notice an amping in my stress response when ingesting, so have backed off of this usage, though my patients who are using have no seeming issues, so it's something in my wiring.

  • 5

    Jury is Out But So Far So Good

    Posted by Gayle on Mar 4th 2022

    First of all, the service is great. I am in Canada and received the product in two weeks. I was really pleased with how securely it was packaged (triple wrapping!). I have been using MB now for two weeks. I have been following the dosage recommended in Mark Sloan's book, "The Ultimate Guide to MB". So far I have noticed an increase in overall energy - I don't feel fatigued throughout the day and especially in the evening. I have also applied it directly to a rash with good results (used a Q tip). I have neuropathy (tingling and occasional numbness) in my hands and have noticed a small decrease. I will continue to increase the dose of MB each week in hopes of it resolving as I have read that MB goes directly to the nervous system. I consume the MB in a glass pf water using a straw and don't have issues with blue teeth or mouth. I appreciate the affordability of this product and the reasonable shipping costs. Thank you Health Natura!

  • 5

    Good customer service

    Posted by Carolyn Robertson on Nov 24th 2021

    This product only just arrived so I am reviewing the Healthnatura service. When my first order didn't arrive, the company was very concerned and sent a second bottle at no extra cost, which arrived promptly. I am sure the product will be as good as the service once I start using it.

  • 3

    Simply methylene blue

    Posted by Pam on May 22nd 2021

    I can’t really give this a good review as I am yet to receive it. I guess I can review the shipping and give it maybe 1. I ordered this on around 21/4 for memory and every time I check the shipping over the last 2 or 3 weeks it’s been sitting at a certain destination still within the U.S. on 5 may. Im in Australia and have read an FAQ to be patient it could take up to 10 weeks! I don’t hold up much hope of getting it as we are travellers travelling around australia we leave this postal address I used for delivery on 5 June so I don’t know what will happen there.

  • 5

    Greatest Quality as Always!

    Posted by Adam Smith on May 12th 2021

    As expected, Health Natura's MB is of the best purity. It's great to have around for a cognitive boost at lower doses and a potent anti-viral at higher doses.

  • 5


    Posted by peter davies on Apr 27th 2021

    improves my memory -works good.

  • 4

    Product is as expected

    Posted by Brenda Aarts on Oct 13th 2019

    Some difficulty in obtaining as every time I went to put items in cart it showed sold out.

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