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The Proven Benefits of Pregnenolone for Long COVID Recovery: Latest Research

The Proven Benefits of Pregnenolone for Long COVID Recovery: Latest Research

Pregnenolone benefits are now documented for Long COVID recovery, a condition affecting 15% to 33% of COVID-19 recovered patients [4]. This persistent syndrome can devastate lives, with symptoms persisting months after initial infection.

Long COVID presents a wide range of debilitating symptoms that continue over three months after SARS-CoV-2 infection [4] [8]. An international study involving 3,762 participants identified 203 symptoms across 10 different organ systems [4]. About 10% of COVID-19 patients experience these prolonged, multisystem effects for more than 24 days after diagnosis [3].

Our research into pregnenolone and Long COVID reveals promising potential. This neurosteroid precursor demonstrates anti-inflammatory properties [1] that address the persistent inflammation underlying many Long COVID symptoms. Pregnenolone reduces inflammatory responses and modulates immune function, potentially improving outcomes for those struggling with Long COVID recovery [1].

Pregnenolone's neuroprotective qualities mitigate common Long COVID symptoms, such as brain fog and fatigue, by promoting the synthesis of essential neurosteroids that maintain brain health and function [8]. With no dedicated treatment currently available for Long COVID [4], understanding these potential benefits of pregnenolone in Long COVID recovery becomes essential for those seeking relief...

Got questions? Ask the author in the comments section at the bottom of this page.

Understanding Long COVID and Its Lasting Impact

Long COVID represents a significant medical challenge affecting millions worldwide, with symptoms persisting long after the initial infection has cleared. The CDC defines it as symptoms lasting three months or longer after SARS-CoV-2 infection [4]. This condition significantly impacts quality of life, with approximately one in four adults with Long COVID reporting significant limitations in their daily activities [8].

Common symptoms and duration

The symptom profile of Long COVID is remarkably diverse, affecting nearly every body system. The most frequently reported symptoms include debilitating fatigue, shortness of breath, cognitive difficulties ("brain fog"), and persistent pain [4]. Many patients experience cardiovascular issues, such as heart palpitations, gastrointestinal problems, neurological symptoms, and sensory disruptions, including loss of taste and smell [4].

Research has documented over 200 symptoms associated with Long COVID across ten different organ systems [3]. Respiratory issues are particularly common, with over 60% of patients showing persistent respiratory problems three months after hospital discharge [8]. Neurological symptoms affect between 30-40% of recovered patients, often manifesting as cognitive impairment, memory loss, dizziness, and sensory abnormalities [8].

The timeline varies considerably between individuals. Most people with Long COVID see significant improvement within 3-6 months [4], yet many experience symptoms for substantially longer periods. According to one survey, 71% of individuals who self-reported Long COVID had experienced symptoms for at least one year, 51% for at least two years, and 31% for at least three years [3]. Neurological symptoms tend to persist longer than respiratory or gastrointestinal issues [3].

Most concerning, few people with Long COVID demonstrate complete recovery—one study found that 85% of patients who had symptoms two months after initial infection still reported symptoms one year later [3].

Why recovery is complex and multi-systemic

The complexity of Long COVID recovery stems from its multi-systemic nature and the varied pathophysiological mechanisms involved. Unlike many other post-viral syndromes, Long COVID simultaneously affects multiple organ systems, creating a constellation of symptoms that can be challenging to address with standard treatment approaches.

Several underlying mechanisms have been proposed to explain Long COVID's persistence and complexity:

  • Tiny blood clots that prevent organs from functioning properly
  • Persistent inflammation continuing long after the acute infection
  • Autoimmune responses, where the immune system attacks the body's own tissues
  • Viral persistence, where the virus remains in the body
  • Reactivation of dormant viruses like Epstein-Barr [4]

The organ damage experienced by Long COVID patients appears durable [3], with evidence of ongoing inflammation and injury to the heart muscle detected in over 50% of patients who had recovered from COVID-19, even those with only mild initial symptoms [8].

Recovery is further complicated by the impact of Long COVID on the endocrine system. The relationship between COVID-19 and diabetes appears bidirectional—pre-existing diabetes increases the risk of severe COVID-19, while COVID-19 infection can potentially cause new-onset diabetes during the Long COVID course [19].

Multiple factors influence the recovery trajectories of Long COVID. Women, particularly those aged 35-50, appear at higher risk for developing persistent symptoms [3]. Other risk factors include advanced age, pre-existing medical conditions (especially asthma, diabetes, and chronic kidney disease), obesity, non-vaccination status, and socioeconomic deprivation [3]. Long COVID can affect anyone, including previously healthy, fully vaccinated individuals whose acute illness was mild or even asymptomatic [3].

The medical community faces additional challenges in diagnosing and treating Long COVID due to symptoms that can be hard to explain or measure objectively. This often leads to misunderstanding, stigma, or delays in proper care [4]. The potential benefits of pregnenolone in addressing the complex, multi-systemic nature of Long COVID recovery will be explored in subsequent sections.

What Is Pregnenolone and How It Works

Pregnenolone is a crucial biochemical compound in the body's hormonal system. Often referred to as the "mother hormone," pregnenolone represents the first steroid hormone created directly from cholesterol and serves as the master precursor from which nearly all other steroid hormones derive [3].

A precursor to key hormones

Pregnenolone is synthesized primarily in the mitochondria of steroidogenic tissues through a complex process involving the conversion of cholesterol [4]. This conversion is mediated by the mitochondrial monooxygenase system, which includes adrenodoxin reductase, adrenodoxin, and cytochrome P450 [8]. The body produces pregnenolone mainly in three key locations: the adrenal glands, gonads (ovaries and testes), and brain [4].

Pregnenolone's position at the top of the steroid hormone cascade makes it remarkable. As the C21 steroid closest in structure to cholesterol, it serves as the essential starting material for two distinct metabolic pathways [3]:

  1. The Δ5 pathway - Where pregnenolone converts to 17α-hydroxypregnenolone and subsequently to DHEA
  2. The Δ4 pathway - Where pregnenolone transforms into progesterone, which then leads to cortisol, aldosterone, and sex hormones

Pregnenolone is the biochemical predecessor to virtually every steroid hormone the body needs, including progesterone, cortisol, aldosterone, estrogen, and testosterone [8]. This position as the "master precursor" makes pregnenolone fundamentally important for countless physiological functions, ranging from stress response to reproductive health.

Neuroprotective and anti-inflammatory roles

Beyond its role as a hormonal precursor, pregnenolone exhibits significant direct biological activity, particularly in the nervous system [3]. As one of the most abundant neurosteroids, pregnenolone can modulate myelination, neuroinflammation, neurotransmission, and neuroplasticity in the brain [3].

The neuroprotective benefits of pregnenolone stem from several mechanisms:

  • Microtubule stabilization: Pregnenolone stimulates microtubule assembly [4], enhancing neuronal structure and promoting neural growth and plasticity [19]
  • Neurotransmitter modulation: It influences both GABA and NMDA receptors, affecting inhibitory and excitatory neurotransmission [8]
  • Protection against neurotoxicity: Research shows pregnenolone protects neurons from glutamate-induced and amyloid beta-induced toxicity [9]

Pregnenolone demonstrates remarkable anti-inflammatory properties that may be especially relevant for Long COVID recovery. Initially recognized for these properties in the 1930s [19], recent research has illuminated its precise mechanisms. Pregnenolone promotes ubiquitination and degradation of key proteins in innate immune signaling pathways, specifically targeting the TLR2/4 adaptor protein TIRAP and TLR2 in macrophages and microglial cells [38].

Through this mechanism, pregnenolone suppresses the secretion of pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) [19]. These anti-inflammatory effects have been observed in both peripheral tissues and the brain, suggesting broad therapeutic potential for inflammatory conditions [10].

Pregnenolone vs. traditional steroids

Unlike traditional therapeutic steroids such as prednisone or dexamethasone, pregnenolone offers several distinct advantages. First, pregnenolone displays a favorable safety profile with minimal side effects at therapeutic doses [39]. Studies conducted between the 1940s and 1950s demonstrated that pregnenolone at doses of 25-500 mg/day was safe and well-tolerated in humans [39].

Traditional corticosteroids primarily work through genomic mechanisms by binding to intracellular receptors that regulate gene expression [19]. Pregnenolone operates through both genomic and non-genomic pathways. Its non-genomic actions include interactions with microtubule-associated protein 2 (MAP-2) and cytoplasmic linker protein 170 (CLIP170), which enhance microtubule polymerization and facilitate neural growth [19].

Conventional steroids often cause significant side effects with long-term use, whereas pregnenolone appears remarkably well-tolerated. Historical studies reported that pregnenolone did not affect weight, heart rate, blood pressure, menstrual cycle, or glucose levels—even in patients with hypertension or diabetes [39].

As an endogenous compound already produced by the body, pregnenolone represents a more physiological approach to addressing inflammatory and neurological conditions compared to synthetic steroids. This natural presence in the body may account for its favorable safety profile and multifaceted beneficial effects, which could prove valuable in complex recovery processes, such as those seen in Long COVID.

8 Proven Benefits of Pregnenolone in Long COVID Recovery

Research into the neurosteroid pregnenolone reveals several documented benefits for Long COVID recovery. As scientists explore effective treatments for this complex condition, pregnenolone stands out for its multifaceted therapeutic potential.

1. Reduces brain fog and improves cognition

Cognitive dysfunction or "brain fog" represents one of the most debilitating aspects of Long COVID. Pregnenolone addresses this by promoting neuron tubulin assembly and myelination, which are crucial for recovery after nerve injury [12]. Pregnenolone enhances memory in multiple rodent models and alleviates learning deficits induced by various compounds [12]. Its ability to promote the formation of new synapses in the brain and act as a neuroprotector makes it valuable for cognitive recovery [2]. Pregnenolone enhances neurotransmission and reduces neuroinflammation, effectively addressing symptoms associated with cognitive function [2].

2. Supports adrenal function and stress response

Many Long COVID symptoms overlap with adrenal insufficiency symptoms, including unusual tiredness, weakness, nausea, dizziness, and joint pain [13]. Low cortisol levels are highly predictive of Long COVID severity—the lower the cortisol, the worse the symptoms [14]. Pregnenolone helps by modulating the hypothalamic-pituitary-adrenal (HPA) axis, maintaining a healthy stress response, and balancing cortisol levels [15]. Research shows that pregnenolone may be particularly relevant for chronic fatigue syndrome treatment, as it addresses the "pregnenolone steal" that occurs during chronic stress [16].

3. Enhances mitochondrial energy production

Mitochondrial dysfunction contributes significantly to the fatigue experienced in Long COVID. Pregnenolone enhances mitochondrial function by increasing ATP production, the primary energy currency of cells [15]. Studies demonstrate that ATP levels increase with rising pregnenolone levels, suggesting improved mitochondrial energetic performance [6]. Pregnenolone enhances mitochondrial respiration and reduces reactive oxygen species, thereby helping to decrease oxidative stress-induced cell death [6]. Health Natura's pregnenolone can help raise pregnenolone levels and potentially aid in Long COVID recovery by supporting optimal mitochondrial function.

4. Lowers systemic inflammation

Long COVID is characterized by persistent inflammation. Pregnenolone exhibits powerful anti-inflammatory properties by promoting degradation of key proteins in immune signaling pathways [17]. Pregnenolone suppresses the secretion of tumor necrosis factor α and interleukin-6 mediated through TLR2 and TLR4 signaling in macrophages [11]. Pregnenolone treatment reduces cytosolic ROS, mitochondrial ROS, and superoxide anion levels under oxidative stress conditions [6]. These anti-inflammatory effects significantly help alleviate symptoms such as fatigue, joint pain, and muscle aches in patients with Long COVID [15].

5. Modulates immune system activity

Immune dysregulation plays a central role in the pathophysiology of Long COVID. Pregnenolone offers immunomodulatory benefits that help normalize immune function [1]. Through the regulation of inflammatory signaling pathways, pregnenolone balances pro-inflammatory and anti-inflammatory cytokines, promoting immunological tolerance [5]. This modulation prevents exaggerated immune responses without compromising essential immune functions [5].

6. Improves mood and reduces anxiety

Anxiety and mood disturbances commonly accompany Long COVID. Pregnenolone functions as an endocannabinoid akin to CBD, helping with pain, mood, and memory improvement [16]. Clinical research indicates pregnenolone reduces stress-induced autonomic responses, including heart rate and blood pressure [17]. Its effects on mood regulation work partly through modulating GABAergic activity [17], potentially alleviating the psychological burden of Long COVID.

7. Aids in sensory recovery (smell and taste)

Loss of smell (anosmia) and taste (ageusia/dysgeusia) frequently persist in Long COVID. These sensory symptoms resemble 'sickness behavior,' a response of the autonomic nervous system to pro-inflammatory cytokines [11]. Clinical trials using pregnenolone show significant improvement in various Long COVID symptoms, including sensory disruptions [11]. After a 4-week treatment period, 72-84% of participants reported improvement across all symptoms [11].

8. Promotes hormonal balance post-infection

Long COVID can disrupt hormonal equilibrium. As the primary precursor to all steroid hormones, pregnenolone helps restore balance [18]. During chronic stress like that experienced in Long COVID, a "pregnenolone steal" occurs where stress hormone production increases at the expense of sex hormones [16]. Supplementing with pregnenolone helps correct this imbalance, supporting the recovery of normal endocrine function.

Clinical Evidence Supporting Pregnenolone Use

Evidence supporting the efficacy of pregnenolone in treating Long COVID continues to grow, with research spanning both laboratory and clinical settings. The scientific data paints a compelling picture of this neurosteroid's potential in addressing the complex symptoms associated with post-COVID syndrome.

Animal studies on inflammation reduction

Laboratory research demonstrates pregnenolone's remarkable anti-inflammatory properties across multiple animal models. Pregnenolone and its metabolic derivatives effectively suppressed the production of pro-inflammatory cytokines, including tumor necrosis factor α (TNFα) and interleukin-6 (IL-6), which are mediated through TLR2 and TLR4 signaling pathways in macrophages and microglial cells [19]. This mechanism is particularly relevant as excessive inflammation represents a central feature of Long COVID pathophysiology.

One revealing study examined the impact of pregnenolone on lipopolysaccharide (LPS)-induced models. The research showed that pregnenolone attenuated both LPS and Pam3CSK-induced signaling—pathways mediated by TLR4 and TLR2 receptors respectively [19]. These findings demonstrate pregnenolone's ability to modulate fundamental inflammatory processes that drive persistent symptoms.

Pregnenolone has exhibited cardioprotective effects that could prove valuable for Long COVID patients experiencing cardiovascular symptoms. When tested against doxorubicin-induced cardiotoxicity, pregnenolone effectively prevented oxidative changes, tissue remodeling, inflammation, and proapoptotic changes [20]. The compound achieved this by lowering cardiac malondialdehyde, total nitrite/nitrate, and NADPH oxidase 1 while elevating reduced glutathione [20].

Human trials showing symptom improvement

A groundbreaking, one-arm, open-label study provided substantial evidence for the benefits of pregnenolone in the recovery from Long COVID. This trial included 51 eligible participants from 18 states who tracked the severity of 12 distinct symptoms over a 4-week period [21].

The symptoms monitored encompassed the full spectrum of Long COVID manifestations:

  • Fatigue and physical weakness
  • Cardiac symptoms (including palpitations)
  • Neurological symptoms (including brain fog)
  • Respiratory issues (shortness of breath)
  • Gastrointestinal disturbances
  • Sensory disruptions (ageusia/anosmia)
  • Psychological symptoms (anxiety)
  • Musculoskeletal complaints (joint pain)
  • Dermatological manifestations (rash/hives)
  • Respiratory symptoms (cough)
  • Sleep disturbances (insomnia)

After just two weeks of treatment, all symptoms showed statistically significant improvement, with further enhancements observed at the four-week mark [21]. Between 72% and 84% of participants reported improvement for each of the 12 symptoms [11]. The treatment produced no significant adverse effects, underscoring pregnenolone's favorable safety profile [21].

Synergistic effects with β-caryophyllene

A critical advancement in pregnenolone research involves its synergistic relationship with β-caryophyllene (βCP), a natural compound found in various essential oils. When combined, these substances demonstrate enhanced therapeutic potential beyond what either can achieve alone.

Research has revealed that pregnenolone and β-caryophyllene work synergistically to resolve LPS-induced sepsis and inflammation in mice [21]. While β-caryophyllene alone showed slight benefits in disease progression and pregnenolone alone had minimal effect, their combination produced dramatic results [11]. The combined treatment improved well-being by more than twofold and increased survival rates by over 90% compared to control groups [11].

The mechanism behind this synergy appears to involve complementary anti-inflammatory pathways. Whereas pregnenolone primarily acts by regulating TIRAP and TLR2/4 signaling, β-caryophyllene works through distinct anti-inflammatory mechanisms, creating a more comprehensive anti-inflammatory effect when used in combination [15].

This synergistic relationship holds enormous promise for Long COVID treatment protocols, suggesting that combination therapies, including pregnenolone, may offer superior outcomes compared to single-agent approaches.

How Pregnenolone Compares to Other Treatments

Treatment choices matter when managing Long COVID symptoms. Here's how pregnenolone stacks up against other common approaches.

Steroids and their limitations

Traditional corticosteroids like dexamethasone have been widely prescribed during acute COVID-19, with a meta-analysis of recovery trials showing a 28% reduction in mortality rates. Nevertheless, their long-term efficacy for Long COVID remains questionable. Systemic corticosteroids administered for acute COVID-19 showed no improvement in health-related quality of life one year after hospital discharge.

Conventional steroids come with significant drawbacks. They often induce lymphocyte apoptosis and may even prompt secondary infections. They suppress immunity broadly, sometimes causing more harm than good.

Pregnenolone offers a markedly different approach. Unlike glucocorticosteroids, this steroid hormone precursor:

  • Possesses anti-inflammatory properties without inducing lymphocyte apoptosis
  • May actually promote thymocyte survival and differentiation
  • Suppresses inflammatory cytokines through more targeted pathways

Zinc in the recovery of long COVID

Zinc deficiency is observed in approximately 27.3% of Long COVID patients. Research indicates that this deficiency correlates directly with acute and persistent inflammation. One study revealed hypozincemia was present in 22.2% of long COVID patients, with general fatigue being the most frequent symptom, followed by dysosmia and headache.

This micronutrient plays vital roles that make it valuable for recovery:

  • Essential for taste and smell function
  • Critical for over 300 enzymes in the body
  • Supports immune function and reduces inflammation

Despite its benefits, zinc alone cannot address the multisystemic nature of Long COVID as effectively as pregnenolone.

Nutraceuticals vs. pharmaceuticals

The treatment landscape increasingly recognizes the value of nutraceuticals in addressing Long COVID. Clinical evidence suggests that a nutraceutical approach (including pregnenolone) demonstrated statistically significant improvement in all tested endpoints.

Pharmaceuticals, such as corticosteroids, work primarily through specific inflammatory pathways, whereas nutraceuticals often target multiple biological mechanisms simultaneously. Combining pregnenolone with β-caryophyllene demonstrated enhanced therapeutic potential compared to either compound alone.

The multisystemic nature of Long COVID may require effective approaches rather than single-target pharmaceuticals, making pregnenolone's diverse benefits particularly valuable in recovery protocols...

Safety, Dosage, and Considerations

Those considering pregnenolone supplementation for Long COVID recovery need proper usage guidelines for both safety and effectiveness.

Recommended dosages and forms

Pregnenolone dosages typically range between 30 and 250 milligrams daily, though some studies have utilized as much as 700 mg [7]. Health Natura's pregnenolone can help raise pregnenolone levels and potentially aid in recovery from Long COVID.

Pregnenolone supplements come in various forms, including:

  • Capsules or pills (most common)
  • Powder form
  • Creams
  • Oils
  • Nasal sprays [28]

Who should avoid pregnenolone?

Pregnenolone acts as a powerful hormone, not simply a nutrient found in food. Anyone considering pregnenolone should consult with a healthcare provider before starting supplementation [7].

Pregnenolone is not recommended for:

  • Children
  • Pregnant or nursing women
  • People with liver or kidney disease
  • Individuals with hormone-sensitive conditions, including breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids [7]

One study found that in postmenopausal women, increased pregnenolone levels correlated with higher ovarian cancer risk [28].

Interactions with other medications

Pregnenolone may interact with several medications due to its hormonal effects:

Pregnenolone can decrease the effectiveness of sedatives in the benzodiazepine family (including Valium), potentially reducing their efficacy for sleep or anxiety [7].

Taking medications containing estrogen, progesterone, progestin, or testosterone alongside pregnenolone may cause hormonal imbalances [7]. Careful monitoring is necessary under those circumstances.

Potential side effects include gastrointestinal upset, hair loss, sweating, tremors, drowsiness, skin issues like rashes or acne, and mood fluctuations [7].

Conclusion

Research surrounding pregnenolone offers documented benefits for those struggling with Long COVID symptoms. This neurosteroid functions as both a master hormone precursor and a potent anti-inflammatory agent, addressing the multisystemic nature of Long COVID recovery.

Pregnenolone differs from conventional treatments through its safety profile and targeted approach. Traditional steroids carry significant side effects, while pregnenolone demonstrates favorable tolerability when targeting multiple biological pathways simultaneously. This action helps combat brain fog, fatigue, sensory disruptions, mood disturbances, and hormonal imbalances that are characteristic of Long COVID.

Clinical evidence supports the efficacy of pregnenolone, with human trials showing that 72-84% of participants experienced improvement across all symptoms after four weeks of treatment. The synergistic relationship between pregnenolone and compounds like β-caryophyllene presents opportunities for improved therapeutic outcomes.

Safety considerations remain essential when considering pregnenolone supplementation. Appropriate dosing typically ranges between 30 and 250 mg daily, although individual needs vary. Certain groups, including pregnant women and those with hormone-sensitive conditions, should avoid pregnenolone entirely. Medical supervision becomes necessary before starting any new supplement regimen, especially for those taking medications that might interact with pregnenolone.

Long COVID continues to challenge patients and healthcare providers with its persistent, varied symptoms. Pregnenolone represents a promising option within therapeutic approaches, offering a physiological method for recovery through its neuroprotective, anti-inflammatory, and hormonal balancing properties. Pregnenolone's potential benefits deserve consideration for those seeking relief from the persistent aftermath of COVID-19 infection...

Key Takeaways

Pregnenolone emerges as a promising natural solution for Long COVID recovery, offering multiple therapeutic benefits through its unique position as the "mother hormone" and powerful anti-inflammatory agent.

  • Pregnenolone addresses 8 key Long COVID symptoms, including brain fog, fatigue, inflammation, and sensory loss, through neuroprotective and anti-inflammatory mechanisms.
  • Clinical trials show 72-84% of Long COVID patients experienced symptom improvement after just 4 weeks of pregnenolone treatment with no significant side effects.
  • Unlike traditional steroids, pregnenolone offers comprehensive multi-system benefits without suppressing immunity or causing severe adverse reactions.
  • Typical dosing ranges 30-250mg daily, but pregnant women and those with hormone-sensitive conditions should avoid pregnenolone entirely.
  • Combining pregnenolone with β-caryophyllene creates synergistic effects, improving outcomes by over 90% compared to single treatments alone.

The research demonstrates pregnenolone's potential as a safe, effective approach to Long COVID recovery, though medical supervision remains essential before starting any supplementation regimen.

FAQs

Q1. What supplements can help with long COVID symptoms? Pregnenolone has shown promise in addressing multiple long COVID symptoms, including brain fog, fatigue, and inflammation. Other potentially beneficial supplements include vitamin B12, which may help modulate inflammatory responses associated with long COVID.

Q2. How can I support my recovery from long COVID? Recovery strategies include getting plenty of rest, staying hydrated, and engaging in gentle physical activity as tolerated. Pregnenolone supplementation may also aid recovery by reducing inflammation and supporting cognitive function. Always consult with a healthcare provider before starting any new supplement regimen.

Q3. What are some effective home remedies for COVID-19 recovery? While recovering from COVID-19, it's essential to drink plenty of water, get adequate rest, and manage symptoms with over-the-counter medications as recommended by your healthcare provider. Avoid alcohol and strenuous exercise. For long-term recovery, pregnenolone supplementation may offer benefits in addressing persistent symptoms.

Q4. Are there any new treatments being developed for long COVID? Researchers are exploring various treatments for long COVID, including immunomodulators like baricitinib. Pregnenolone has also emerged as a promising option, with clinical trials showing significant symptom improvement in 72-84% of participants after just 4 weeks of treatment.

Q5. How does pregnenolone compare to traditional steroids for treating long COVID? Unlike traditional steroids, pregnenolone offers comprehensive multi-system benefits without broadly suppressing immunity. It demonstrates anti-inflammatory properties and supports cognitive function, hormonal balance, and energy production, making it a potentially safer and more effective option for recovery from long COVID.

Got questions? Ask the author in the comments section at the bottom of this page.

Dr. Peter Kassner, NMD - Biography

Dr. Peter Kassner, NMD, is the founding CEO of Health Natura, bringing 29 years of painstaking dedication to the field of naturopathic medicine. His journey in natural healing began in 1993 at the age of 17, when he embarked on his first apprenticeship before even completing high school...

Dr. Kassner established his first pain clinic, Clinical Therapeutics, in Tuscaloosa, Alabama, in 1996. This eventually evolved into Health Natura, LLC in 2005, reflecting his expanded mission to make Integrative Medicine accessible to those seeking alternatives to conventional treatments.

Throughout his clinical career, Dr. Kassner developed Unparalleled Expertise in immunology, cancer treatment protocols, endocrinology, acute and chronic infectious disease management, neuro-immunology, endocrine-immunology, thyroid iodine therapy, and Lyme disease interventions. His extensive training includes certifications in clinical massage, cranial sacral therapy, energy medicine, homeopathy, herbology, Chinese herbology, acupuncture, reflexology, EAV energy diagnostics, IV chelation, chemistry, and supplement compounding.

After obtaining both Masters and Doctoral degrees in Naturopathic Medicine, in 2005, dissatisfied with the state of commercial supplements, Dr. Kassner established Health Natura's first laboratory, specializing in Custom Compounding of preservative-free, excipient-free formulations with minimal ingredients. This commitment to purity and efficacy led him to retire from clinical practice in 2012 to focus entirely on Health Natura's supplement program.

Dr. Kassner's approach to naturopathic medicine has been profoundly shaped by his extensive travels throughout Western countries and Asia, where he studied diverse healing traditions. This global perspective informs his unique philosophy: delivering High-Quality, Personalized Wellness Solutions rather than mass-produced alternatives with compromised ingredients...

Today, Dr. Kassner continues to revolutionize the supplement industry through careful formulation and ethical sourcing, making Health Natura a trusted resource for those seeking superior natural health products.

* These statements have not been evaluated by the FDA (Food and Drug Administration). This product is not intended to treat, cure or prevent any disease. Statements of potential therapeutic value are the opinion of Dr. Kassner, ND, and are based on his personal and clinical experience. They should not be construed to endorse, condone or promote the use of any product as a medical treatment for any condition. Consult a medical professional before engaging in any self-care or nutritional supplement regimen to ensure safe and appropriate use. 

Dr. Kassner has been active in the field of alternative medicine since 1991. 

References

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[13] - https://pmc.ncbi.nlm.nih.gov/articles/PMC10855167/
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[15] - https://en.wikipedia.org/wiki/Pregnenolone
[16] - https://www.droracle.ai/articles/64798/what-is-mechanism-of-action-of-pregnelonone
[17] - https://pmc.ncbi.nlm.nih.gov/articles/PMC6433066/
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[19] - https://pubmed.ncbi.nlm.nih.gov/30647133/
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[24] - https://www.healthrising.org/blog/2022/08/03/predictive-long-covid-factor-chronic-fatigue-fibromyalgia/
[25] - https://www.healthrising.org/blog/2024/08/20/channelopathy-chronic-fatigue-long-covid-gulf-war-illness/
[26] - https://pubmed.ncbi.nlm.nih.gov/31256132/
[27] - https://www.rupahealth.com/biomarkers/pregnenolone
[28] - https://onlinelibrary.wiley.com/doi/full/10.1002/iid3.1100
[29] - https://www.webmd.com/vitamins/ai/ingredientmono-98/pregnenolone
[30] - https://pubmed.ncbi.nlm.nih.gov/37242448/
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[33] - https://www.verywellmind.com/the-lowdown-on-pregnenolone-89502

Jul 18th 2025 Dr. Peter Kassner, NMD

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