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Progesterone therapy is a widely used hormone replacement therapy that women have used for several decades. Progesterone, an essential hormone in both men and women, plays a vital role in the menstrual cycle, pregnancy, emotional balance, and overall well-being. Traditionally, bioidentical HRT (Hormone Replacement Therapy) or progesterone hormone therapy is prescribed by a physician and made by a compounding pharmacy. However, the popularity of over-the-counter creams that are applied topically …