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Why Women Need Testosterone: The Science Behind LJ100 and Testofen

Why Women Need Testosterone: The Science Behind LJ100 and Testofen

Women require testosterone for optimal health. Testosterone supplements for women support fertility, sex drive, menstrual health, bone density, muscle mass, mood, memory, and motivation [35]. This isn't theory—it's established science.

Testosterone decline hits women hardest during perimenopause and menopause. Decreased libido tops the list of complaints [35]. Unexplained fatigue follows closely. Low mood and cognitive changes round out the symptoms [28]. Around age 50, ovaries stop producing estrogen [35]. Testosterone decline deserves equal attention.

Natural testosterone supplements for women deliver results without prescriptions. LJ100® (Eurycoma longifolia) and Testofen® (Fenugreek Seed Extract) lead the field. Women over 40 showed improvements of up to 133% in hand grip strength with LJ100® [28]. Menopausal women reported 33% better quality of life [28].

These results are derived from carefully formulated and standardized extracts. LJ100® uses roots from plants aged five years minimum. Testofen® contains 50% Fenuside™, the active compound. Both ingredients target testosterone optimization through natural pathways.

The evidence supports testosterone's critical role in women's health, sexual wellness, physical strength, and mental wellbeing...

Got questions? Ask the author in the comments section at the bottom of this page.

Why Testosterone Matters for Women

Women's most crucial hormone gets ignored. Testosterone is the most abundant biologically active hormone in women's bodies [28]. Smaller quantities than men, yes. Impact on female physiology? Virtually every system.

This isn't speculation—it's measurable science. Ovaries and adrenal glands produce testosterone continuously. Additional amounts form in tissues and cells throughout the body. Normal levels range from 15-70 nanograms per deciliter. Each measurement matters for hormonal balance.

The role of testosterone in female physiology

Testosterone production occurs primarily through the ovaries and adrenal glands, with additional synthesis happening in tissues and cells throughout the body [28]. Normal testosterone levels range from 15-70 nanograms per deciliter (ng/dL) [28]. This range helps maintain hormonal balance across various bodily functions.

The physiological impact reaches every system. Testosterone helps:

  • Improve ovarian function and regulate menstrual cycles [28] [7]
  • Strengthen bones and prevent osteoporosis [28] [28]
  • Support muscle development and maintain muscle tone [28][35]
  • Regulate mood and reduce anxiety [28][35]
  • Enhance cognitive abilities and memory [28] [28]
  • Maintain healthy energy levels [28][35]
  • Support immune function and stress resilience [31]

Sexual health depends heavily on adequate testosterone levels. The hormone drives libido and arousal mechanisms [7]. Cardiovascular protection represents another critical function, with research confirming testosterone's heart-protective effects [28].

The decline starts earlier than most women realize. Testosterone levels begin to drop by age 30, with a more significant reduction starting around age 35 [35]. This early decline explains symptoms that appear decades before menopause...

Common misconceptions about testosterone for women

Myths about testosterone and women's health persist despite clear scientific evidence. The biggest misconception? Testosterone is exclusively a "male hormone." Science demonstrates women need testosterone for optimal physical and mental well-being [28] [5].

Testosterone therapy causes masculinization in women. Wrong. Appropriately administered testosterone therapy doesn't cause a deepened voice or excessive hair growth [28] [35]. Dose-dependent effects mean lower doses actually "stimulate femininity" [28].

Women fear that testosterone therapy causes hoarseness, hair loss, or aggressive behavior. No scientific evidence supports these concerns [28]. Testosterone therapy has been shown to increase scalp hair growth in women [28]. It stabilizes mood rather than increases aggression [28][12].

Heart issues with testosterone therapy worry some women. Research shows testosterone is cardiac protective [28]. Bioidentical testosterone therapy hasn't shown adverse cardiovascular effects in women [31]. Synthetic androgens and anabolic steroids differ entirely from bioidentical testosterone.

Facts about natural testosterone supplements for women dispel unfounded fears. Proper testosterone levels throughout a woman's life provide genuine benefits without the risks associated with misconceptions.

How Hormones Shift with Age

Hormonal changes start earlier than most women realize. Testosterone decline begins before menopause, creating changes years before hot flashes appear.

How Hormones Shift with Age

Testosterone decline during perimenopause and menopause

Testosterone decline starts in the late 20s—much earlier than estrogen [35]. By approximately half by age 40, levels drop significantly [5]. Menopause finds women already experiencing 20 years of declining testosterone [35].

Surgical menopause creates different challenges than natural menopause. Ovary removal causes testosterone to plummet, decreasing by up to 50% in some studies [35]. Natural menopause doesn't significantly impact testosterone beyond age-related decline [35].

Women in their 70s experience a resurgence in testosterone levels [6]. Scientists suggest that this provides survival benefits, although research continues on the underlying mechanism.

Impact on mood, libido, and energy

Testosterone decline creates a symptom cluster affecting quality of life:

  • Decreased sexual desire and satisfaction [20]
  • Persistent fatigue and lowered energy levels [7]
  • Mood changes, including irritability, anxiety, and depression [36]
  • Cognitive issues such as "brain fog" and memory problems [20]
  • Reduced muscle strength and tone [37]

One in three women struggles with low sexual desire [38]. Menopause amplifies libido changes. Adequate testosterone supports both desire and arousal [5].

Testosterone regulates mood directly. Low levels link to increased anxiety, depression, and unexplained fatigue [9]. Women report feeling "not themselves" with decreased motivation and unexplained mood swings.

Differences between estrogen and testosterone decline

Estrogen drops more dramatically than testosterone during menopause, creating "relative androgen excess" [10]. The testosterone-to-estrogen ratio increases approximately 10.1% annually during menopausal transition [10].

Estrogen declines 12% yearly during perimenopause, while testosterone decreases 3.1% annually [10]. This shifting balance affects metabolism and mood beyond what estrogen-focused treatments address.

Natural testosterone supplements for women become relevant during this hormonal shift. LJ100® Eurycoma longifolia and Testofen® Fenugreek Seed Extract work with natural processes rather than against them...

The Science Behind LJ100® and Testofen®

Plant extracts help maintain hormone balance in women. LJ100® and Testofen® lead with research-backed benefits. Health Natura's Testosterone Matrix contains the proper herbs to naturally boost testosterone in women.

What is LJ100® (Eurycoma longifolia)?

LJ100® is a patented, standardized extract of Eurycoma longifolia, commonly known as Tongkat Ali or Malaysian ginseng [11]. Premium extraction uses roots from plants aged five years minimum for potency and consistency [4].

LJ100® standardization: 40% glycosaponins and 22% eurypeptides [4]. These bioactive compounds balance hormones through multiple pathways:

  • Hormonal Pathway: LJ100® activates the CYP17 enzyme, enhancing conversion of pregnenolone into DHEA, testosterone, and progesterone while balancing cortisol [4]
  • Stress Reduction: Clinical studies show LJ100® reduces cortisol levels by up to 16% in stressed individuals [12]
  • Hormone Availability: Inhibits Sex Hormone Binding Globulin (SHBG), increasing free bioavailable testosterone [4]

LJ100® helps the body produce and optimize its own hormone levels naturally [4].

How Testofen® (Fenugreek extract) supports testosterone

Testofen® is a specialized fenugreek (Trigonella foenum-graecum) seed extract standardized to 50% Fenuside™, a proprietary saponin glycoside matrix [13]. Clinical studies demonstrate healthy testosterone support through unique mechanisms.

Testofen® displaces bound testosterone. 98% of bloodstream testosterone remains bound to proteins and is inactive. Displacing just 1% effectively doubles free, bioavailable testosterone [14]. Hormone levels stay within physiological limits [14].

Clinical research shows Testofen® impacts body composition. Combined with resistance training, participants experienced reduced body fat, increased lean muscle mass, and improved strength and endurance [1]. Ideal for women seeking to maintain muscle tone during the aging process.

Clinical studies supporting their use in women

Both ingredients provide compelling evidence of benefits for women's health.

119 healthy women aged 41-55 with perimenopausal and postmenopausal symptoms participated in randomized clinical trials. Eurycoma longifolia formulations significantly reduced hot flashes while improving hormone profiles and overall quality of life [15]. Animal studies using ovariectomy models demonstrated LJ100® improved hormonal levels disrupted by the procedure [15].

Testofen® research proves particularly promising. Studies show a 70% increase in free estradiol levels in women, with similar increases in free testosterone [14]. Clinical trials involving healthy women in stable relationships who complained of low sexual desire showed Testofen® supplementation increased sexual activity by 100% over eight weeks [14].

Both supplements demonstrate excellent safety profiles when used as directed, making them appropriate choices for women seeking natural testosterone support.

Key Benefits of Testosterone Support in Women

Optimal testosterone levels deliver measurable improvements across multiple health markers. These benefits explain why natural testosterone supplements are gaining increasing attention for hormonal balance.

Improved libido and sexual wellness

Low sexual desire affects women significantly, particularly after menopause [16]. Testosterone regulates desire, arousal, and satisfaction through both central nervous system and peripheral tissue effects [17].

Clinical evidence proves testosterone therapy's effectiveness. Seven randomized trials with over 3,000 women showed increased satisfying sexual episodes, enhanced sexual activity, improved orgasm frequency, and stronger desire [16]. Testosterone increases vaginal blood flow, enhancing sensitivity and orgasm likelihood [17].

Enhanced muscle strength and bone density

Free testosterone levels correlate directly with muscle mass, strength, and bone microarchitecture [17]. Higher testosterone shows a positive association with lumbar bone mineral density in women aged 40-60 years [18] [18].

Testosterone acts directly on osteoblasts via androgen receptors [3]. It promotes osteoblast differentiation while inhibiting bone breakdown [3]. This dual action effectively prevents age-related bone loss.

Better mood, memory, and motivation

Transdermal testosterone therapy for 4 months produced mood improvements in 47% of women, alongside significant cognitive enhancements [19].

Testosterone strengthens brain nerves, contributes to mental sharpness, and regulates serotonin levels [20]. It stimulates dopamine release, improving pleasure and motivation [20]. Three symptoms most likely to improve: "loss of interest in most things" (56%), "crying spells" (55%), and "loss of interest in sex" (52%) [19].

Support for immune function and stress resilience

Testosterone's immune effects depend on reproductive context rather than universal suppression [21]. This hormone coordinates immune resources effectively [21].

Throughout menstrual cycles, testosterone regulates inflammatory markers, such as IL-6 [21]. It modulates the stress response by reducing cortisol levels, enhancing emotional resilience, and helping women cope with life's challenges [22].

Natural testosterone supplements provide these benefits without synthetic hormone therapy concerns, making them effective for maintaining optimal hormone balance...

Choosing the Right Supplement Strategy

Supplement selection requires careful evaluation. Natural and pharmaceutical approaches each carry distinct considerations.

Natural vs. synthetic testosterone options

Bioidentical hormones derive from plant sources like soy and yams. These match your body's molecular structure exactly. Synthetic options differ molecularly from women's endogenous hormones [2]. The FDA approves certain bioidentical hormones but not custom-compounded formulations [2].

Non-prescription alternatives offer proven benefits. LJ100® (Eurycoma longifolia) and Testofen® (Fenugreek extract) provide science-backed results. Health Natura's Testosterone Matrix contains the proper herbs to naturally boost testosterone in women.

Safety, dosage, and monitoring considerations

Women need significantly less testosterone than men [7]. Side effects include acne and increased hair growth at application sites. Facial hair growth, voice deepening, or hair loss typically don't occur when levels stay within the female physiological range [9].

Prescription options are most effective when administered through transdermal applications rather than oral forms, which can have a negative impact on cholesterol levels [23]. Baseline measurements and follow-up monitoring after 3-6 weeks are recommended [24]. Discontinue any supplement showing no benefits after 6 months [24].

Quality matters. Standardized extracts deliver consistent results. Generic supplements often lack proper standardization and potency verification.

Conclusion

Testosterone deficiency affects women's health more than previously understood. The hormone supports sexual wellness, bone health, muscle tone, mood regulation, and cognitive function. Decline begins in the late 20s—not at menopause.

LJ100® and Testofen® offer clinically proven alternatives to synthetic hormone therapy. These standardized plant extracts optimize testosterone levels within normal physiological ranges. Clinical studies demonstrate effectiveness for sexual function, physical strength, and quality of life improvements.

Women need accurate information about complete hormonal health. Estrogen-focused treatments miss testosterone's equally important role. This explains why some women continue experiencing symptoms despite conventional hormone therapy.

Optimized testosterone benefits extend beyond physical health. Mood, memory, and motivation improve when testosterone deficiency is addressed. Proper levels support immune function and stress management capabilities.

Unexplained fatigue, low libido, or mood changes may indicate testosterone deficiency. Natural supplements provide gentle support for this critical hormone. Multiple aspects of well-being improve with proper hormonal balance as women age.

Your hormonal health requires a comprehensive approach—one that acknowledges testosterone as an essential component of overall wellness...

Key Takeaways

Understanding testosterone's role in women's health can transform how you approach hormonal wellness and aging. Here are the essential insights every woman should know:

Testosterone is women's most abundant active hormone, supporting libido, bone density, muscle strength, mood, and cognitive function throughout life.

Testosterone decline starts in your late 20s—20 years before menopause—causing fatigue, low libido, and mood changes, many women don't connect to hormones.

Natural supplements like LJ100® and Testofen® offer science-backed testosterone support without synthetic hormone risks, with studies showing up to 133% strength improvements.

Optimal testosterone levels enhance sexual wellness, muscle tone, bone health, and mental clarity while supporting immune function and stress resilience.

Unlike estrogen-focused treatments, addressing testosterone decline targets the root cause of many perimenopausal and menopausal symptoms that conventional therapy misses.

The key is recognizing that hormonal health isn't just about estrogen—testosterone plays an equally vital role in helping women maintain vitality, strength, and well-being as they age.

FAQs

Q1. Can women benefit from testosterone supplements like Testofen? Yes, women can benefit from testosterone supplements like Testofen. Clinical studies have shown that Testofen can increase free testosterone and estradiol levels in women, leading to improved sexual function and desire. It's particularly effective for women experiencing low libido.

Q2. What are the main benefits of healthy testosterone levels for women? Healthy testosterone levels in women support bone density, muscle mass, cognitive function, mood regulation, sexual wellness, and energy levels. It plays a crucial role in maintaining overall physical and mental well-being throughout a woman's life.

Q3. How do testosterone levels change as women age? Testosterone levels in women begin to decline in their late 20s, significantly earlier than estrogen levels. By age 40, levels can drop by approximately half. This gradual decrease continues through perimenopause and menopause, potentially affecting various aspects of health and well-being.

Q4. Are natural testosterone supplements safe for women? Natural testosterone supplements like LJ100® and Testofen® have demonstrated excellent safety profiles when used as directed. Unlike synthetic hormone therapy, these plant-based extracts work with the body to optimize testosterone levels without pushing them beyond normal physiological ranges.

Q5. How can women tell if they might benefit from testosterone support? Women experiencing unexplained fatigue, decreased libido, mood changes, difficulty maintaining muscle tone, or cognitive issues like "brain fog" may benefit from testosterone support. These symptoms, especially when occurring during perimenopause or menopause, could indicate suboptimal testosterone levels.

Got questions? Ask the author in the comments section at the bottom of this page.

Dr. Peter Kassner, NMD - Biography

Dr. Peter Kassner, NMD, is the founding CEO of Health Natura, bringing 29 years of painstaking dedication to the field of naturopathic medicine. His journey in natural healing began in 1993 at the age of 17, when he embarked on his first apprenticeship before even completing high school...

Dr. Kassner established his first pain clinic, Clinical Therapeutics, in Tuscaloosa, Alabama, in 1996. This eventually evolved into Health Natura, LLC in 2005, reflecting his expanded mission to make Integrative Medicine accessible to those seeking alternatives to conventional treatments.

Throughout his clinical career, Dr. Kassner developed Unparalleled Expertise in immunology, cancer treatment protocols, endocrinology, acute and chronic infectious disease management, neuro-immunology, endocrine-immunology, thyroid iodine therapy, and Lyme disease interventions. His extensive training includes certifications in clinical massage, cranial sacral therapy, energy medicine, homeopathy, herbology, Chinese herbology, acupuncture, reflexology, EAV energy diagnostics, IV chelation, chemistry, and supplement compounding.

After obtaining both Masters and Doctoral degrees in Naturopathic Medicine, in 2005, dissatisfied with the state of commercial supplements, Dr. Kassner established Health Natura's first laboratory, specializing in Custom Compounding of preservative-free, excipient-free formulations with minimal ingredients. This commitment to purity and efficacy led him to retire from clinical practice in 2012 to focus entirely on Health Natura's supplement program.

Dr. Kassner's approach to naturopathic medicine has been profoundly shaped by his extensive travels throughout Western countries and Asia, where he studied diverse healing traditions. This global perspective informs his unique philosophy: delivering High-Quality, Personalized Wellness Solutions rather than mass-produced alternatives with compromised ingredients...

Today, Dr. Kassner continues to revolutionize the supplement industry through careful formulation and ethical sourcing, making Health Natura a trusted resource for those seeking superior natural health products.

* These statements have not been evaluated by the FDA (Food and Drug Administration). This product is not intended to treat, cure or prevent any disease. Statements of potential therapeutic value are the opinion of Dr. Kassner, ND, and are based on his personal and clinical experience. They should not be construed to endorse, condone or promote the use of any product as a medical treatment for any condition. Consult a medical professional before engaging in any self-care or nutritional supplement regimen to ensure safe and appropriate use. 

Dr. Kassner has been active in the field of alternative medicine since 1991. 

References

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[6] - https://my.clevelandclinic.org/health/diseases/24897-low-testosterone-in-women
[7] - https://www.nesaz.com/the-role-of-testosterone-in-womens-health/
[8] - https://dutchtest.com/articles/role-of-testosterone-perimenopausal-menopausal-women
[9] - https://pubmed.ncbi.nlm.nih.gov/26358173/
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[11] - https://www.sciencedirect.com/science/article/pii/S0378512213000121
[12] - https://www.southurogyn.com/blog/myths-about-testosterone-for-women/
[13] - https://lj100.com/blog/formulating-for-mood-and-performance-lj100s-adaptogenic-effects/
[14] - https://wellnessobgyn.com/low-testosterone-in-women/
[15] - https://www.nytimes.com/2025/02/04/well/testosterone-therapy-menopause.html
[16] - https://www.drlouisenewson.co.uk/knowledge/the-importance-of-testosterone-for-women
[17] - https://health.clevelandclinic.org/low-testosterone-in-women
[18] - https://www.bumc.bu.edu/sexualmedicine/publications/testosterone-insufficiency-in-women-fact-or-fiction/
[19] - https://utswmed.org/medblog/libido-testosterone-women/
[20] - https://pmc.ncbi.nlm.nih.gov/articles/PMC7098532/
[21] - https://pmc.ncbi.nlm.nih.gov/articles/PMC2950016/
[22] - https://lj100.com/clinical-studies-library/
[23] - https://lj100.com/faqs/
[24] - https://www.gencorpacific.com/ingredients/testofen
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[33] - https://pmc.ncbi.nlm.nih.gov/articles/PMC5303633/
[34] - https://yoursuperiorwellness.com/the-role-of-testosterone-in-womens-mental-health/
[35] - https://pmc.ncbi.nlm.nih.gov/articles/PMC9331845/
[36] - https://www.medicalnewstoday.com/articles/best-testosterone-supplements
[37] - https://menopause.org.au/health-info/resources/testosterone-and-women
[38] - https://www.va.gov/formularyadvisor/DOC_PDF/CRE_Testosterone_HSDD_Clinical_Summary_Mar_2025.pdf

Sep 26th 2025 Dr. Peter Kassner, NMD

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