LipoFlow

EDTA is an effective chelating agent used to remove toxic metals from the system. Lipoflow Liposomal EDTA gel is a fully absorbed into the blood stream through the CI tract without side effects. This product is a true alternative to intravenous injections.

The oral absorption of EDTA powders or pills from the GI tract into the blood stream is very inefficient (less than 5%). In addition, there is a side effect that even small amounts of EDTA can cause instant diarrhea.

Liposomes consist of Essential Phospholipids (EPL), which are natural substances that form the outer membrane of every living cell in humans and animals. (Below find a description of the additional vascular benefits of Lipoflow EPL products.)

The size of these spheres is very small, in the order of nanometers. As illustrated, the spheres are hollow inside and contain the liquid material in which they were formed (inclusion). Because of the small size of the phospholipid molecule and nanospheres, they can pass through biological membranes and act as a carrier for enclosed substances. Lipoflow uses a natural blend of highly refined Phospholipids from soy lecithin which is used to form closely packed liposome gels. Each cellular structure (vesicle) contains the desired pharmaceutical solution for delivery through the respective membrane. The first figure below depicts an electron microscope image of such a gel. As the image shows, there is very little space left between the vesicles, which contains the same material that is inside. Once this gel has been formed it is stable and can be diluted and added to oral products for delivery through the respective membranes.

Directions: Gently stir product into 2 oz of water or juice and take orally.

Physicians: Dose and frequency of oral administration is the same as for intravenous administration.

Liposomal EDTA is available in 2 oz. and 4 oz. sizes

Serving Size: 1 ounce (1000 mg EDTA)

Each Serving Contains: Essential Phospholipids (5500 mg), disodium EDTA

(1000 mg), Magnesium Chloride (70 mg), Alpha-Lipoic Acid (50 mg).

Other Ingredients: Water, lecithin, sodium benzoate (preservative). No sugar, No

starch, No artificial colors. No artificial flavors. No wheat. No gluten. No dairy. Also Available: EDTA Ca (1000 mg/oz Calcium Disodium EDTA, 50 mg/oz Alpha LipoicAcid, 5500mg/oz Essential Phospholipids).

LIPOFLOW® LIPOSOMAL NANOTECHNOLOGY for NUTRITIONAL SUPPLEMENTS’~

References and Abstracts on the Benefits of Essential Phospholipids (EPL)

Pharmakinetics of EPL

The relative absorption rates of radioactive phospholipids in man were higher than 90%. The authors were able to show that approx. 40% - 80% of EPL absorbed were incorporated into the vasoprotective HDL (so called “good cholesterol”). The authors further concluded that part of the EPL were absorbed un-metabolized. This explains the relative long lifetime (48 hours) of liposomes in the human system. See Zierenberg, 0., S.M. Grundy, J. Lipid Research 23(1982)1136-1142

Clinical Studies on EPL

In a documentation of 15 clinical trials with a duration of EPL treatment ranging between 1 and 12 months, total serum cholesterol was lowered by 8.8 to 28.2%. See Fasoli, A., Therap. Select. Risk/Benefit Assess Hypolipid. Drugs; G. Ricci et al. (Eds) Raven Press: NewYork 1982, 257-262

In a double blind trial by the authors using 1.8 g oral EPL per day led to mean reductions of total cholesterol by 12.7%

already within 14 days of treatment, After another4 weeks reduction of initial values totaled 18.9%. See Horsch AK. etal.,

VASA15 (1986) 275-279

After oral EPL treatment up to 16 weeks, mean rates of cholesterol reduction in these studies that were either controlled

against diet, double blind, controlled against placebo or were open, ranged from 12 to 25% as compared with initial values.

See Casellas Bernat, G. et al. Olin. Med. 15 (1975) 90 -95; Skorepa, J. et al., Casopis Lekaru Oekych 113 (1974) 784-

786; Yasugi, T., Jap. J. New Rem. Olin 22 (1973) 691 -693

While diet alone did not produce satisfactory reductions in most cases, it clearly enhanced the effect of diets on serum lipids when applied together with EPL. See Knuechel, F. Die Medizinische 36 (1959) 1652 - 1653; Varkonyi, C. Zschr. Ges. Med. Grenzgeb. 18 (1962) 830-835

The author conducted a controlled study (n=32) and reported mean elevation in HDL cholesterol (so called “good cholesterol”) of 25%. See Maeda,A. etal. Gendai no Shinryo22 (1980)189-192 and 1461 -1465

The following authors give a wide range of reduction rates of triglycerides with values 25% being the most common. See Dewailli, P. et al., Med. Welt 36 (1985) 367-369; Yasugi, T., Jap. J. New Rem. Olin. (1973) 691 -693; Yoritsune, M. et al., Gendai no Shinryo 22 (1980) 836 -842

This author describes a significant inhibition of platelet adhesion as well inhibition of platelet aggregation in blood after administration of oral EPL. See Ooccheri, S. etal.,Acta. Med. Scan. 190 Suppl. 525 (1971) 253 -256

This author confirmed an improved passage of red blood cells through microfilters due to increased fluidity of the blood after injecting EPL. See Blagosklonov, S.S. et al., Kardiologyia 26 (1986) 35-38

Significant decreases in anginal attacks (chest pain stage III ans IV) or in some patients total elimination of anginal attacks

as well as increased exercise tolerance of as much as 900% are reported. See Almazov, V.A. et aI. Lipostabil Symp.

Moscow, Nov 1984 Almazov, V.A. et aI. Kardiologyia 26 (1986) 39-42 Hevelke G. et al. Med. Welt 30 (1980) 593 -602 ltkina,

L.D. et aI. Lipostabil Symp. Moscow, Nov 1984 Seki, H. et al. Gendai Iryo 6 (1974) 599 -618 Spesivtseva, V.G. et aI.

Lipostabil Symp. Moscow, Nov 1984

Administration of EPL to patients with stages I through IV of heart disease in a controlled study demonstrated an improved blood flow in the muscles of the lower extremities after 30 days of treatment. The author attributes this improvement to reduced blood viscosity resulting in improved peripheral circulation. See Klemm, J. in Phosphatidylcholine. H. Peeters (ed.) Springer: Berlin 1976, 237 -243

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